摘要
目的研究血脂联素瘦素比值与老年男性代谢综合征的相关性。方法选择老年男性患者256例，分为代谢综合征组109例和非代谢综合征组（对照组）147例，代谢综合征的诊断采用2004年中国糖尿病学会制定的标准；采用LINCO放射免疫试剂盒测定空腹血脂联素、瘦素水平。结果（1）老年男性代谢综合征组与对照组瘦素水平分别为（10．3±7．0）μg／L和（6．8±4．9）μg／L，脂联素分别为（7．8±5．6）g／L和（9．5±5．9）g／L，脂联素瘦素比值分别为0．94±0．78和2．15±2．13；（2）脂联素瘦素比值与体质指数、血三酰甘油、血尿酸水平均呈负相关，而与高密度脂蛋白水平显著正相关（P〈0．001）；（3）随着脂联素瘦素比值升高，代谢综合征发生的可能性减小，当比值在5以上，代谢综合征的患病率降至0（χ^2=34．891，P〈0．001）；（4）代谢异常组分数越多，脂联素瘦素比值越低（F=10．876，P〈0．001）。结论血脂联素瘦素比值可用于评价老年男性患者代谢紊乱程度，对老年男性代谢综合征的诊断有辅助作用。
Objective To explore the correlation between adiponectin/leptin（A/L） ratio and metabolic syndrome diagnosis in elderly men. Methods A total of 256 elderly men （≥60 years） were enrolled and divided into metabolic syndrome group（n= 109） and non metabolic syndrome group （n= 147）. Serum levels of adiponectin and leptin were measured by radioimmunoassay （RIA） and the A/L ratio was calculated. Metabolic syndrome diagnosis is based on the definition provided by China Diabetes Society （CDS） in 2004. Results （1） In metabolic syndrome group versus non metabolic syndrome group, the serum levels of leptin and adiponectin were （10.3±7.0） vs （6.8±4.9） μg/L and（7.8±5.6）g/L vs （9.5±5.9）g/L, and A/L ratio was 0.94±0.78 vs 2.15±2.13 respectively. （2） A/L ratio was positively correlated with high density lipoprotein cholesterol （HDL-C） and negatively correlated with body mass index （BMI）, triacylglycerol （TG） and serum uric acid （P〈 0. 001）. （3） The higher value of A/L ratio, the lower possibility of metabolic syndrome. When the A/L ratio was more than 5 ,the incidence of metabolic syndrome was decreased to 0（χ^2 =34. 891 ,P〈 0.001）. （4） The more components of metabolic abnormality, the lower value of A/L ratio（F= 10. 876,P〈0. 001）. Conclusions The A/L ratio may be useful in evaluating the extent of metabolic disorder and diagnosing metabolic syndrome in elderly men .
出处
《中华老年医学杂志》
CAS
CSCD
北大核心
2009年第7期567-569,共3页
Chinese Journal of Geriatrics
基金
上海市科委资助项目（034119816）
关键词
脂联素
瘦素
代谢综合征
Adiponectin
Leptin
Metabolic syndrome X
