摘要
目的动态观察骨质疏松性骨折愈合的组织学变化与特征，进一步阐明骨质疏松性骨折的愈合方式。方法选择８０只８月龄、雌性ＳＤ大鼠，手术方法为建立骨质疏松性骨折（ＯＰＦＭ）与一般骨折（ＣＦＭ）的实验模型各４０只，于术后５天、１、２、４、６、８、１２、１６周截取骨痂组织作光镜与偏光镜观察。结果与一般骨折愈合方式相似，软骨内成骨与膜内成骨共同参与了骨质疏松性骨折的修复，且以软骨内成骨为主。但骨质疏松性骨折愈合过程中，软骨内成骨延缓，骨性骨痂改建（骨吸收＞骨形成）加速，骨痂内胶原纤维疏松、排列紊乱，与主应力方向不一致，从而导致骨折愈合质量降低。结论骨质疏松性骨折愈合质量较一般性骨折有所降低。
Objective To dynamically observe the histological alterations and characteristics of osteoporotic fracture healing, and to further elucidate its mode of healing. Methods 80 female 8 month old SD rats were randomized into two groups of 40 each: the osteoporotic fracture model(OPFM) and the common fracture model(CFM). The callus of each rat was examined by light microscope or polarized microscope in 5 days and 2,4,6,8,12 and 16 weeks postoperatively. Results In OPFM, both endochondral bone formation and intramembrane bone formation played their parts in osteoporotic fracture healing, the former played a major role. But during the healing process, endochondral bone formation delayed, while bony callus tissue remodeling accelerated(bone resorption>bone formation), collagenous fibers in callus tissue arranged loosely and irregularly in and being in consistent with the direction of the principal stress. Conclusion Compared with the common fracture healing, quality of the osteporotic fracture healing can decrease. (Shanghai Med J. 1999,22:137 139)
出处
《上海医学》
CAS
CSCD
北大核心
1999年第3期137-139,I000,共4页
Shanghai Medical Journal
关键词
骨质疏松性
骨折
骨折愈合
组织学
Osteoporotic fracture Fracture healing Histology
