摘要
目的：本研究的目的是探讨黄芪在裸鼠体内的免疫增强及抑瘤作用．方法：将体外培养的人鳞癌细胞株ＧＮＭ接种于２０只裸鼠皮下，建立移植瘤模型，观察黄芪和平阳霉素及两者联合应用时对ＧＮＭ细胞移植瘤的抑瘤效果，并对结果用免疫组化方法检测．结果：黄芪、平阳霉素、联合用药的抑瘤率分别为６０．４％、７５．３％、８４．５％，用药组与对照组移植瘤体积变化有显著性差异（ｐ＜０．０１）．黄芪及联合用药组的脾细胞密度和ＮＫ细胞活性高于平阳霉素及对照组（ｐ＜０．０１）．结论：黄芪对ＧＮＭ细胞株有明显的抑瘤作用，与平阳霉素合用具有免疫增强和增效作用；黄芪促进ＮＫ细胞活性，参与机体免疫．
The purpose of this study is to explore the immunoenhancement and anti-cancer effect of astragalus membranaceus on human squamous cell carcinoma cell line GNM.The method was to implant GNM cells to the subcutaneous tissue of 20 nude mice and form tumor.We observed the tumor inhibition rates of astragalus and pingyangmycin in nude mice,and examined the cytotoxic activities of NK cells in splenic cell.The results showed that the inbibition rates of the three experimental gruops were 60.4%,75.3% and 84.5% and percentage of NK eytotoxicity were 4.420.98%,2.310.91%,and 4.410.85%,respectively,The results proved that astragalus cembranaceus had a good anti-cancer effect in human squamous cell carcinoma.
出处
《口腔医学》
CAS
北大核心
1999年第2期60-61,共2页
Stomatology
关键词
黄式
GNM细胞
NK细胞
免疫增强
抗癌效应
鳞癌
Astragalus membranaceus GNM cell*7/8NK cell Immunologic enhancement Anti-cancer effect
