摘要
采用酶标免疫组织化学法（ＡＢＣ法）分析妊高征患者及正常产妇胎盘中一氧化氮合成酶Ⅲ（ＮｉｔｒｉｃＯｘｉｄｅＳｙｎｔｈｅｔａｓｅ，ＮＯＳ３）的表达及分布。结果表明：ＮＯＳ３阳性染色颗粒位于合体滋养层细胞及血管内皮细胞胞浆内，ＮＯＳ３染色阳性率正常产妇组为（２１．６５±５．４４）％，妊高征组较正常产妇组明显升高，轻中度为（４３．２６±５．０７）％，重度为（５０．１４±５．１１）％，且轻中度与重度患者间有显著性差异（Ｐ＜０．０５）。提示：ＮＯＳ３浓度的升高，可能是妊高征病程中的一种保护性机制或代偿反应。
By using enzyme labeling immunohistochemistry (ABC) method, the expression and distribution of nitric oxide synthetase (NOS3) of the placenta in patients with pregnancy induced hypertension (PIH) and the health pregnant women in their late pregnancy were detected. It was found that NOS3 positive immunostaining particles were located in the cytoplasm of the syncytiotrophoblast and endothelium. The NOS3 positive rate of placenta in the patients with PIH was increased significantly as compared with that in the healthy pregnant women (2165%544%) and related to the severity of PIH (4326%507% for mildmoderate, 5014%511% for severe). It was suggested that NOS3 elevation might be a protective or compensative mechanism during the duration of PIH.
出处
《同济医科大学学报》
CSCD
1999年第3期262-264,共3页
Acta Universitatis Medicinae Tongji
关键词
妊娠高血压
综合征
胎盘
一氧化氮合成酶
nitric oxide synthetase
\ pregnancy complications, cardiovascular
\ placenta
