摘要
目的观察利多卡因对老年患者术后早期认知功能障碍(POCD)的影响。方法择期行全麻下髋关节置换术老年患者60例,随机均分为利多卡因(L)组和生理盐水(N)组。气管插管后,L组静注利多卡因(负荷量0.5 mg/kg,维持量0.5 mg.kg-1.h-1至术毕);N组静注等容的生理盐水。评估术前24 h和术后48 h简易智力状态检查(MMSE)评分;记录麻醉期BP、HR和SpO2。结果术后48 h,L组患者POCD发生率10%(3/30),明显低于N组的26.7%(8/30)(P<0.05)。与术前比较,L组术后MMSE评分无明显改变,N组则明显下降(P<0.05)。结论静脉输注利多卡因可减少全麻下行髋关节置换术老年患者早期POCD的发生。
Objective To observe the effect of lidocaine on postoperative cognitive dysfunction（POCD） in the elderly undergoing total hip replacement（THR）.Methods Sixty elder patients undergoing selective THR were equally randomized into 2 groups.After tracheal intubation,lidocaine 0.5mg/kg was intravenously injected in group L,which was followed with 0.5mg·kg-1·h-1 infusion until the end of operation.Normal saline was infused in group N.Mini-mental state examination（MMSE） score was evaluated at 24 h before and 48 h after operation.MAP,HR,and SpO2 were recorded during surgery.Results The incidence of POCD was lower in group L than that in group N（10.0% vs.26.7%）（P0.05）.Compared to before,postoperative MMSE score had no significant changes in group L,which was decreased in group N（P0.05）.ConclusionIntravenous infusion of lidocaine during operation may reduce the incidence of early POCD in the elderly undergoing THR under general anesthesia.
出处
《江苏医药》
CAS
CSCD
北大核心
2010年第22期2646-2647,共2页
Jiangsu Medical Journal
关键词
利多卡因
术后认知功能障碍
老年
Lidocaine
Postoperative cognitive dysfunction
Geriatrics
