摘要
目的探讨氟马西尼对老年患者全麻后早期认知功能的影响。方法择期全麻下行非心脏手术老年患者120例,随机分为两组,氟马西尼组(实验组):拔管后静脉注射氟马西尼0.5mg;对照组:拔管后静脉注射等容量生理盐水。分别于注药后30min(T1)、1h(T2)、2h(T3)、24h(T4)采用简易智力状态检查法(MMSE)评估患者的认知功能。结果两组术后MMSE评分均低于术前,差异有统计学意义(P<0.05);实验组在各观察时点与对照组相比,MMSE评分差异有统计学意义(P<0.05),两组术后认知功能障碍(POCD)的发生率差异有统计学意义(P<0.05)。结论老年患者全麻后容易发生认知功能下降,氟马西尼能促进老年患者术后早期认知功能的及早恢复。
Objective To investigate the effect of flumazenil on early postoperative cognitive function in elderly patients with general anesthesia.Methods The 120 elderly patients scheduled for selective non-cardiac surgery under general anesthesia were randomly divided into 2 groups;flumazenil group（experimental group） received the intravenous injection of 0.5 mg flumazenil,while the control group received equally saline after extubation.The cognitive function of patients in both groups were tested with mini-mental state examination（MMSE） in 30 min（T1）,1 h（T2）,2 h（T3）,24 h（T4） after the administration of flumazenil.Results MMSE scores of both groups were significantly decreased as compared with that before operation（P0.05）;MMSE scores in different time points between flumazenil group and control group had statistical difference（P0.05）.Conclusion Postoperative cognitive dysfunction is common in elderly patients with general anesthesia,flumazenil could reverse some cognitive dysfunction resulted from general anesthesia.
出处
《中华全科医学》
2010年第11期1364-1365,共2页
Chinese Journal of General Practice
关键词
氟马西尼
老年患者
认知功能障碍
Flumazenil
Elderly patients
Cognitive dysfunction
