摘要
目的为研究高强噪声对豚鼠听功能的影响。方法２４只豚鼠随机分成对照、１１５ｄＢ（Ａ）暴露和１１８ｄＢ（Ａ）暴露三组，每组８只。观察分析了粉红噪声暴露３ｍｉｎ，豚鼠的鼓膜、毛细胞及听力的变化。结果耳镜检查两暴露组鼓膜无明显损伤；但两暴露组都出现了明显的暂时性听阈偏移（ｔｅｍｐｏｒａｒｙｔｈｒｅｓｈｏｌｄｓｈｉｆｔ，ＴＴＳ）；耳蜗铺片观察两暴露组都发现了毛细胞损伤（Ｐ＜０．０１）。两暴露组的ＴＴＳ３０ｍｉｎ内没有恢复到暴露前水平。与１１５ｄＢ（Ａ）暴露组相比，１１８ｄＢ（Ａ）组毛细胞损伤更严重，ＴＴＳ增大更明显（Ｐ＜０．０５）。
Objective To investigate the effects of high-intensity noise on hearing organ.
Methods 24 guinea pigs were randomly divided into three groups(8 each): normal control
group,115 dB(A) noise exposure group and 118 dB(A) noise exposure group. Changes of
eardrum, hair cell and hearing threshold were observed in guinea pigs after 3 minute exposure
to 115 dB(A) and 118 dB(A) pinknoise level. Result (1) No obvious damage of eardrum was
found in both two noise exposure groups with otoscopy; but obvious temporary threshold shift
(TTS) of hearing was observed in both groups;(2) Significant damage of hair cell was observed
in both exposure groups by morphological analysis of the cochlea( P <0.01);(3) TTS in both
exposure groups didn't recover to the preexperiment level within half an hour;(4) TTS and
damage of hair cell were more severe in 118 dB(A) noiseexposure group than those in 115
dB(A) group ( P <0.05). Conclusion Short time 115 dB(A) noise exposure can cause damage on
hearing organ.
出处
《航天医学与医学工程》
CAS
CSCD
1999年第3期217-219,共3页
Space Medicine & Medical Engineering
关键词
噪声
豚鼠
听力
暂时性听阈偏移
听器损伤
noise
guinea pig
hair cell
hearing
temporary threshold shift(TTS)
