摘要
目的:探讨住院病人药物不良反应(ADRs)的发生率。方法:采用回顾性调查方法,结合自愿呈报ADRs报表方法,对1997年4月至1998年3月期间住院的11354例病人进行了分析。结果:病历调查法所得到的ADRs数量明显多于自愿呈报系统,与ADRs“真实”发生率较为接近;ADRs的临床表现以消化系统最多见;引起ADRs的药物分布以抗生素的品种数最多,而较为严重的ADRs以解热止痛药及器官移植药发生率为高。结论:必须加强临床医生、护理人员在ADRs监护中的主动性,使ADRs能及时呈报,使数据收集更加准确。
To investigate the incidence of adverse durg reactions (ADRs) in inpatients, 11 354 inpa-tients were surveyed retrospectively from April, 1997 to March 1998 by using both voluntary reporting and case-investigation. Our results showed that the number of ADR cases obtained by case-investigation was sig-nificantly greater than that by voluntary reporting and was closer to 'real' incidence. It was found the more ADRs were of gastrointestinal nature. Most ADRs were caused by antibiotics and the serious ADRs were associated with antipyretics and analgesics and drugs used for organ-transplantation. We are led to conclude that effort has to be made to encourage the medical workers to be more actively involved in the ADRs surveillance to ensure the timeliness and accuracy of ADRs data collection.
出处
《药物流行病学杂志》
CAS
1999年第2期79-81,共3页
Chinese Journal of Pharmacoepidemiology
关键词
药物不良反应
发生率
回顾性调查
自然呈报率
Adverse drug reactions i Incidence
Retrospective survey
Voluntary reporting
Medical records
