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寄生虫表面抗原变异及其机制研究进展 被引量：3

Surface antigenic variation and its mechanisms in parasites
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摘要 一些病原体通过不断改变暴露于其表面的抗原分子,从而逃避宿主的免疫压力,形成慢性感染。在此过程中涉及多种不同的抗原变异机制。本文对变异频繁的寄生虫布氏锥虫、恶性疟原虫、蓝氏贾第鞭毛虫的表面抗原变异及其机制研究现状进行了综述。 To maintain chronic infections under the immune pressure generated by hosts,several micro-organisms spontaneously switch the expression of their surface antigens.Different mechanisms are involved in this process.This review summarizes new discoveries in surface antigenic variation and mechanisms used by Trypanosoma brucei,Plasmodium falciparum,and Giardia lamblia,which frequently exhibit antigenic variation.
作者 郭秀霞 王云华
机构地区 大连大学医学院
出处 《中国病原生物学杂志》 CSCD 2010年第11期877-879,共3页 Journal of Pathogen Biology
基金 国家自然科学基金项目(No.30872207 30901253)
关键词 布氏锥虫 疟原虫 恶性 蓝氏贾第鞭毛虫 抗原变异 综述 Trypanosoma brucei Plasmodium falciparum Giardia lamblia antigenic variation review
分类号 R38 [医药卫生—医学寄生虫学]
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参考文献22

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同被引文献77

  • 1田占成,刘光远,白启.锥体科寄生原虫赖以生存的机制及其应用前景[J].动物医学进展,2005,26(7):27-30. 被引量：1
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中国病原生物学杂志
2010年 第11期

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