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HSP47在肺纤维化中的作用机制 被引量：3

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摘要 肺纤维化（PF）是由各种原因引起的弥漫性肺部炎症疾病，其病理特征是肺炎症损伤、成纤维细胞灶的形成、细胞外基质过度沉积，最终导致了肺组织结构的异常重塑。目前，PF的发病机制尚不明确。近年来，细胞因子成为研究疾病发病机制的热点，如TGF-β1、IFN-γ、TNF-α、PDCF、IGF-1、IL-1和IL-8等，它们相互作用，相互协调，形成一个复杂的细胞因子网络，在PF形成中起着重要的调控作用。
作者 汤艳 郑金旭
机构地区 江苏大学附属医院
出处 《山东医药》 CAS 北大核心 2010年第49期117-118,共2页 Shandong Medical Journal
基金 卫生部科研项目(wkj2006-2-026) 江苏省"333工程"资助项目(苏人才办2007-16-09)
关键词 热休克蛋白47 肺纤维化 作用机制
分类号 R563.1 [医药卫生—呼吸系统]
  • 相关文献

参考文献11

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  • 5Nagai N,Hosokawa M,Itohara S,et al.Embryonic iethality of molecular chaperone hsp47 knockout mice is associated with defects in collagen biosynthesis[J].J Cell Biol,2000,150(6):1499-1506.
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  • 7Ishida Y,Kubota H,Yamamoto A.Type I collagen in Hsp47-null cells is aggregated in endoplasmic reticulum and deficient in N-propeptide processing and fibrillogenesis[J].Mol Biol Cell,2006,17(5):2346-2355.
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二级参考文献9

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共引文献3

同被引文献44

  • 1王佐林,张萍,陈万涛,张志愿,邱蔚六.HSP47和TGFβ1在大鼠皮肤瘢痕形成中的作用[J].口腔颌面外科杂志,2004,14(4):293-298. 被引量：5
  • 2Kakugawa T, Mukae H, Hayashi T, et al. Pirfenidone attenuates expression of HSP47 in murine bleomycin-induced pulmonary fibrosis. Eur Respir J, 2004,24 :57-65.
  • 3Nakayama S, Mukae H, Sakamoto N, et al. Pirfenidone inhibits the expression of HSP47 in TGF-betal-stimulated human lung fibroblasts. Life Sci,2008,82:210-217.
  • 4Hong S, Park K, Kim JH,et al. Role of heat shock protein 47 in transdifferentiation of human tenon's fibrohlasts to myofibroblasts. BMC Ophthalmol, 2012,12 : 49.
  • 5Taguchi T, Nazneen A, Al-Shihri AA, et al. Heat shock protein 47: a novel biomarker of phenotypically altered collagen-producing cells. Acta Histochem Cytochem, 2011, 44,35-41.
  • 6Szolajska E, Chroboczek J. Faithful chaperones. Cell Mol Life Sci, 2011,68 : 3307-3322.
  • 7Kakugawa T, Mukae H, Hishikawa Y,et al. Localization of HSP47 mRNA in routine bleomycin-induced pulmonary fibrosis. Virchows Arch, 2010,456 : 309-315.
  • 8Ishida Y, Yamamoto A, elimination of misfolded endoplasmic reticulum as a Cell, 2009,20 : 2744-2754.
  • 9Kitamura A, et al. Autophagic procollagen aggregates in the means of cell protection. Mol Biol Thomson CA, Tenni R, Ananthanarayanan VS. Mapping Hsp47 binding site(s) using CNBr peptides derived from type I and type II collagen. Protein Sci,2003,12:1792 1800.
  • 10Marutani T, Yamamoto A, Nagai N, et al. Accumulation of type IV collagen in dilated ER leads to apoptosis in Hsp47- knockout mouse embryos via induction of CHOP. J Cell Sci,2004,117(Pt 24):5913-5922.

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山东医药
2010年 第49期

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