摘要
目的:比较阿法骨化醇口服冲击与每日口服两种方法治疗维持性血透患者继发性甲状旁腺功能亢进(SHPT)的疗效及对钙、磷水平的影响。方法:将46例维持性血透患者随机分为口服冲击组及每日口服组。比较两组患者治疗前及治疗4、8周后的iPTH、血钙及血磷的水平变化。结果:(1)口服冲击和每日口服两种方法在治疗8周时总达标率分别为100%、73.91%;(2)口服冲击治疗起效快,并对治疗前iPTH>500 ng/L的患者具有更高缓解率;(3)治疗中两组患者的血钙、磷水平均有上升,以每日口服组较为明显。结论:阿法骨化醇每日口服常规剂量和口服冲击两种疗法对继发性甲旁亢均有较好的疗效;但冲击治疗见效快,是一种安全有效的方法。
Objective：To compare oral alfacalcidol two ways to shock and daily oral treatment of hemodialysis patients with secondary hyperparathyroidism（SHPT）and its effect on calcium and phosphorus levels of impact Methods：46 cases of hemodialysis patients were randomly divided into two groups：Oral Impact Group and Daily oral administration group.Comparison before treatment and after treatment 4,8 weeks of iPTH,calcium and phosphorus changes.Results：（1） daily oral administration of oral impact in two ways in the treatment of 8 weeks the overall compliance rate was 100%,73.91%; （2） rapid onset of oral pulse therapy,and pre - treatment iPTH500 ng / L of the patients had a higher response rate;（3 ） in the treatment of patients in both groups serum calcium,phosphorus levels have increased to a daily oral administration group are obvious.Conclusion：alfacalcidol oral standard - dose and oral pulse therapy for secondary hyperparathyroidism have a good effect;but quick pulse therapy is a safe and effective means.
出处
《黑龙江医药》
CAS
2010年第1期37-39,共3页
Heilongjiang Medicine journal
