摘要
目的探讨膳食钙摄入等级与围绝经妇女骨丢失速度的关系。方法采用营养流行病学的方法,从湖南省妇幼保健院围绝经期门诊常规体检的妇女189名进行膳食钙FFQ调查和骨密度测量,同时进行问卷调查并进行随访,对两次测量的骨丢失速度进行估计,采用秩和检验比较不同膳食钙摄入组间骨丢失速度的差异;采用多元方差分析分析膳食钙摄入对围绝经期妇女骨丢失的影响。结果观察期间189名妇女各个部位骨密度均有所下降,腰椎L2-4,Wards三角区,总髋部,股骨颈,大转子各部位丢失速度分别为0.56%、0.53%、0.51%、0.49%和0.34%。膳食钙对各部位骨丢失速度影响不同(Z=21.57,P=0.00)。不同膳食钙等级妇女股骨颈、总髋部和腰椎骨丢失速度不同(P分别为0.000、0.015和0.0119)。膳食钙摄入最低组的骨丢失速度最快。调整其他因素的影响后,不同膳食钙等级仍然与妇女股骨颈、总髋部骨丢失速度有关,膳食钙与腰椎骨丢失的关系不再显著。与膳食钙摄入大于等于851.7mg/d(膳食钙充足)相比,FFQ钙摄入低于505.6mg/d者股骨颈骨丢失速度是充足组的2.12倍(P=0.000),髋部总骨骨丢失速度是充足组的1.33倍(P=0.004);膳食钙可以解释股骨颈骨丢失速度的24.5%和髋部总骨骨丢失速度的19.9%。结论该研究结果证明,对于围绝经期妇女,膳食钙达到851.7mg/d对于骨丢失,特别是股骨颈和髋部总骨量丢失具有保护作用。
【Objective】To assess the association of dietary calcium intake and bone loss in perimenopausal women in Changsha. 【Method】189 healthy premenopausal women who went to Hunan Provincial Maternal and Child Health institute for periodic medical examination were enrolled for this 1 year follow up study. Dietary intake was assessed by the food frequency questionnaires, and BMD of various skeletal sites were measured by Dual energy Xray absorptiometry （DXA） at baseline and 12-13 months. The association between mean dietary intake over the follow-up period and the rate of bone loss was examined. 【Results】189 women all experienced bone loss during 1year＇s follow-up, the total loss rates of BMD at the L2～4, Ward＇s triangle, Total hip, Femoral neck and trochanter were 0.56%, 0.53%, 0.51%, 0.49% and 0.34% respectively. Subjects were stratified into four quartiles according to calcium intake FFQ, women in different quartiles has significant bone loss at the femoral neck （P 0.001）, total hip （P =0.015） and Spine 2-4 （P =0.019）. Subjects in quartile I had significantly higher BMD loss rate. After adjustments for confounding factors by mutivariate analysis of variance, significant associations between calcium intake and BMD change at the total hip and femoral neck was observed, and no significant effect of calcium intake at the spine was found. Comparing to women in quartile IV （calcium intake higher than 851.7 mg/d）, women in quartile I （calcium intake lower than 505.6 mg/d ） experienced 2.12 times faster bone loss in femoral neck （P =0.000） and 1.33 times faster in total hip （P = 0.004）. Dietary Ca intake accounted for 24.5% and 19.9% of the variations in BMD change at the femoral neck and total hip, respectively.【Conclusion】Our findings suggest that dietary calcium intake had a beneficial effect on bone loss at the total hip and femoral neck of the hip. an intake exceeding 851.7 mg calcium per day was helpful in the prevention of cortical bone loss among peri-menopausal Changsha women.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第5期713-717,722,共6页
China Journal of Modern Medicine
基金
国家科技攻关计划"老年疾病医疗后果评价系统的研究"(No:2001BA702B05)
关键词
膳食钙
骨丢失
围绝经期
营养流行病学
Dietary calcium intake
bone loss
perimenopausal women
nutritional epidemiology
