摘要
目的研究院前急救中应用普罗帕酮治疗阵发性室上性心动过速的疗效及安全性。方法选取该院急诊阵发性室上性心动过速患者,随机分成普罗帕酮和维拉帕米治疗组。普罗帕酮组给予普罗帕酮35mg静脉推注,若无效,继续用普罗帕酮70mg缓慢静脉滴注(30滴/min)。维拉帕米组给予维拉帕米5～10mg静脉推注。记录是否转复以及转复前后心电图参数改变、血压改变等。结果维拉帕米组在20min内转复为窦性心律的患者为75%,平均复转时间为(14.62±4.39)min;普罗帕酮组为转复为窦性心律的患者为93%,平均复转时间为(9.61±1.47)min,两组疗效差异和评价复转时间差异均具有统计学意义(P<0.05)。维拉帕米组未转复前基线PR间期为(172.4±20.5)ms,复转后降为(159.3±19.4)ms;普罗帕酮组未转复前基线PR间期为(173.1±19.4)ms,复转后降为(132.1±14.2)ms,差异均具有统计学意义(P<0.05)。维拉帕米组治疗后QRS间期延长为(81.3±2.4)ms;普罗帕酮组治疗后QRS间期延长为(89.2±4.5)ms,两组比较差异明显(P<0.05)。给药后转复前的RR间期两组均明显延长,差异均具有统计学意义(P<0.05)。维拉帕米组伴高血压病的患者收缩压(20.7±2.9)kPa下降至(16.3±1.8)kPa,舒张压从(14.7±2.6)kPa下降至(12.6±1.7)kPa,治疗前后差异具有统计学意义(P<0.05)。普罗帕酮组伴高血压病的患者收缩压(20.1±2.3)kPa下降至(14.1±1.1)kPa,舒张压从(4.8±1.2)kPa下降至(4.8±1.2)kPa,治疗前后差异均具有统计学意义(P<0.05)。两组治疗后收缩压和舒张压变化幅度均具有统计学意义(P<0.05)。未出现严重的副反应和相关的血生化改变。结论普罗帕酮治疗阵发性室上性心动过速,疗效显著且不良反应轻微。
【Objective】To observe the efficacy and safety of Propafenone in the treatment of paroxysmal supraventricular tachycardia during first aid.【Methods】906 cases paroxysmal supraventricular tachycardia were randomly divided into Propafenone treatment group and Verapamil treatment group.In the Propafenone group 35 mg Propafenone were administered by intravenous injection,if invalid,continued to use the slow intravenous infusion of 70 mg of Propafenone（30 drops/min）.In the Verapamil group 5～10 mg of Verapamil were given.After rehabilitation,ECG parameters,blood pressure changes were studied.【Results】Verapamil group within 20 min to rehabilitation for patients with sinus rhythm was 75%,the average transit time is（14.62±4.39） min;Propafenone group to rehabilitation for patients with sinus rhythm was 93%,with an average time for rehabilitation is（9.61±1.47） min,the rehabilitation effects of time of both groups have statistically significant difference（P〈0.05）.PR interval of Verapamil group was（172.4±20.5） ms,and it reduced to（159.3±19.4） ms after therapy;of which in Propafenone Group reduced to（132.1±14.2） ms,the differences are statistically significant（P〈0.05）.After treatment QRS interval prolongation of Verapamil group is（81.3±2.4） ms;of which in Propafenone group extended to（89.2±4.5） ms,obvious difference between the two groups（P〈0.05）.To rehabilitation after administration of the RR interval before the two groups were significantly prolonged,the differences are statistically significant（P〈0.05）.Verapamil group of patients with hypertension with systolic blood pressure（20.7±2.9） kPa decreased to（16.3±1.8） kPa,diastolic blood pressure from（14.7±2.6） kPa decreased to（12.6±1.7） kPa,with a statistical difference between before and after treatment（P〈0.05）.Propafenone group of patients with hypertension with systolic blood pressure（20.1±2.3） kPa decreased to（14.1±1.1） kPa,diastolic blood pressure decreased from（4.8±1.2） kPa to（4.8±1.2） kPa,the difference before and after treatment were statistically significance（P〈0.05）.After treatment changes in systolic and diastolic blood pressure between both groups were statistically significant margin（P〈0.05）.No serious side effects and related biochemical changes in blood.【Conclusion】Propafenone has significant efficacy and minor adverse reactions in the treatment of paroxysmal supraventricular tachycardia.
出处
《中国现代医学杂志》
CAS
CSCD
北大核心
2010年第3期406-409,共4页
China Journal of Modern Medicine
关键词
阵发性室上性心动过速
普罗帕酮
院前
paroxysmal supraventricular tachycardia
Propafenone
pre-hospital
