摘要
目的：观察ｎｍ２３基因在膀胱癌中的表达并探讨其临床意义。方法：对４７例膀胱癌标本进行Ｓ－Ｐ免疫组化染色，分析ｎｍ２３蛋白表达与膀胱癌多种指标和预后的关系。结果：ｎｍ２３蛋白在膀胱癌组织及非癌粘膜中均有表达，定位于细胞浆。７２．３４％的膀胱癌组织ｎｍ２３蛋白染色阳性，阳性率显著高于非癌粘膜（Ｐ＜０．０５）。ｎｍ２３蛋白高度表达与膀胱癌细胞的低度分化及局部浸润有关，与肿瘤复发及肿瘤大小无关。结论：在膀胱癌中ｎｍ２３基因可能不是转移抑制基因，相反却促进膀胱癌的发生和发展，ｎｍ２３蛋白对于判断膀胱癌细胞的恶性程度、肿瘤进展以及预后有价值。
Objective: We studied the expression of nm23 protein in bladder carcinoma
in order to evaluate its clinical significance. HZMethods: We studied the expression of nm23
protein in 47 cases of bladder carcinoma by the method of SP immunohistochemistry. The
relationship between nm23 protein expression and several parameters and prognosis of
bladder carcinoma were analyzed. Results: The expression of nm23 protein was detected in
both bladder carcinoma tissue and noncarcinoma mucosa and the nm23 protein was located in
cytoplasm. 72.34% of bladder carcinoma were positively stained; the positive rate was higher
than that of noncarcinoma tissue (P<0.05). The high expression rate of nm23 protein was
associated with poor differentiation and local infiltration, but it was not associated with age and
sex of the patients as well as the tumor size. Conclusion: BZThe nm23 gene in bladder
carcinoma could not be a metastasis suppressor gene, on the contrary, it could promote the
genesis and progression of bladder might be of some value to judge the malignancy and
progression together with prognosis.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
1999年第3期210-212,共3页
Journal of China Medical University
关键词
NM23蛋白
免疫组织化学
膀胱肿瘤
nm23 protein
immunohistochemistry
bladder
neoplasmcarcinoma
examination of nm23
