摘要
目的:探讨烧伤患者血浆降钙素基因相关肽(CGRP)和内皮素(ET)水平与烧伤后消化道溃疡的相关性。方法:采用放射免疫法测定61例烧伤患者、51例烧伤后消化道溃疡患者和30例对照组血浆CGRP、ET水平。结果:烧伤患者血浆CGRP水平为(27.18±11.21)ng/L、烧伤后消化道溃疡患者血浆CGRP水平为(22.64±10.42)ng/L,显著低于正常对照组(60.31±26.17)ng/L(P<0.01);烧伤患者血浆ET水平为(103.31±38.51)ng/L、烧伤后消化道溃疡患者血浆ET水平为(290.34±57.10)ng/L,显著高于正常对照组(40.61±11.51)ng/L(P<0.01)。结论:血浆CGRP/ET之间平衡紊乱可能在烧伤后消化道溃疡的发生机制中具有重要作用。
Objective：To investigate the relation between the levels of serum calcitonin gene-related peptide（CGRP）/endothelin（ET）and after-burn peptic ulcer.Methods：The levels of serum CGRP and ET from 61cases of burn without peptic ulcer,51cases of burn with peptic ulcer,and 30 normal subjects were detected by radioimmunoassay.Results：The serum CGRP levels were（27.18±11.21）and（22.64±10.42）ng/L respectively for the groups of burn without and with peptic ulcer,and both were significantly lower than that of normal group（both P0.01）.The levels of serum ET were（103.31±38.51）ng/L and（290.34±57.10）ng/L respectively for the two burn groups and both were much higher than that of normal group（both P0.01）.Conclusion：There may be a relationship between the balance disorder of CGRP/ET and after-burn peptic ulcer.
出处
《武汉大学学报（医学版）》
CAS
北大核心
2010年第6期836-837,共2页
Medical Journal of Wuhan University
