摘要
目的观察术后帕瑞昔布钠注射液联合硬膜外自控镇痛(PCEA)对患者肝肾功能及PCEA用药量的影响。方法在硬膜外麻醉下接受妇科手术的60例患者随机分为两组(n=30),其中帕瑞昔布钠+PCEA组患者于手术关腹后静脉注射帕瑞昔布钠40mg后连接PCEA泵(0.005%吗啡+0.24%甲磺酸罗哌卡因),PCEA组患者则于手术关腹后仅连接PCEA泵(0.005%吗啡+0.24%甲磺酸罗哌卡因)。术后24h检测两组患者的肝肾功能指标;于术后4、8、12和24h时点,采用视觉模拟评分法(VAS)进行疼痛评分,同时观测PCEA按压次数和用药总量。结果患者手术前后自身对照比较显示,肝肾功能指标均无明显变化(P>0.05)。帕瑞昔布钠+PCEA组术后4、8、12和24h时点VAS疼痛评分及PCEA按压次数和用药总量均明显低于PCEA组,差异均有统计学意义(P<0.05或P<0.01)。两组患者均未添加其他辅助镇痛药。结论帕瑞昔布钠用于术后镇痛对肝肾功能无明显影响,且能明显增强镇痛效果,减少PCEA用药量。
Objective To observe the influence of postoperative application of parecoxib sodium combined with patient-controlled epidural analgesia （PCEA） on hepato-renal function and drug consumption of PCEA.Methods Sixty women undergoing epidural anesthesia were randomly divided into 2 groups （n=30）.Patients in parecoxib sodium＋PCEA group were intravenously injected with 40 mg parecoxib sodium after abdominal closure,and were then managed with PCEA pump （0.005% morphine＋0.24% ropivacaine mesylate）,while patients in PCEA group were only managed with PCEA pump （0.005% morphine＋0.24% ropivacaine mesylate） after abdominal closure.Parameters of hepato-renal function were measured 24 h after operation.Visual analogue scale （VAS） scores were obtained 4,8,12 and 24 h after operation,and palping times of PCEA and drug consumption of PCEA were recorded meanwhile.Results There was no significant change in parameters of hepato-renal function after operation in both groups（P0.05）.VAS scores,palping times of PCEA and drug consumption of PCEA 4,8,12 and 24 h after operation in parecoxib sodium＋PCEA group were significantly lower than those in PCEA group（P0.05 or P0.01）.There was no additional analgesic medication for both groups.Conclusion Parecoxib sodium for postoperative analgesia has no significant influence on hepato-renal function,while it can obviously enhance the analgesic effect and decrease the drug consumption of PCEA.
出处
《上海交通大学学报（医学版）》
CAS
CSCD
北大核心
2010年第11期1405-1407,共3页
Journal of Shanghai Jiao tong University:Medical Science
关键词
帕瑞昔布钠
硬膜外自控镇痛
肝肾功能
镇痛
parecoxib sodium
patient-controlled epidural analgesia
hepato-renal function
analgesia
