摘要
目的:应用Meta分析综合评价缓激肽β2受体(Bradykininβ2 receptor,BDKRβ2)基因-58T/C多态性与高血压病(Hypertension)发病风险之间的相关性。方法:检索并筛检电子数据库中符合纳入标准的BDKRβ2基因-58T/C多态性与高血压病关系的病例对照研究文献,应用RevMan 5.0和SPSS13.0统计软件对各研究结果进行异质性分析,选择适当的分析模型进行数据定量合并估计其效应,同时进行种族亚组分层分析和发表偏倚的评估。结果:共纳入10篇文献,12项研究共计1 736例高血压病患者,1 682例对照。Meta分析结果显示:BDKRβ2基因-58T/C多态性CC基因型携带者的高血压病发病风险是CT和TT基因型携带者的1.36倍(P=0.03)。按不同种族亚组分层分析显示:在日本人群,中国汉族人群和非洲裔美国人群亚组中的CC基因型与高血压病的发病风险存在相关性(P<0.05),而高加索人群亚组CC基因型与高血压病的发病之间的关系尚不明确(P=0.85)。结论:缓激肽β2受体基因-58T/C多态性CC基因型可能增加高血压病的发病风险,但具有显著的种族差异。
Objective：Toevaluate syntheticallythe association between bradykinin β2 receptor（BDKRβ2）gene-58T/C polymorphism and the risk of hypertension with Meta-analysis. Methods ：In electronic databases,the literatures of case-control trials of the relation between BDKR β2 gene-58T/C polymorphism and the hypertension risk were searched,which met the inclusion criteria.Statistical analysis was performed with RevMan 5.0 and SPSS 13.0 to investigate heterogeneity;then suitable models were selected for data combination and effect evaluation and to undertake the analysis of ethnic subgroups and the evaluation of publication bias. Results： Totally,10 literatures,12 studies,1 736 cases and 1 682 controls were included. The Meta analysis showed that the hypertension risk of carriers of BDKRβ2 CC genotype was 1.36 times as much as the risk of carriers of CT or TT genotype （P=0.03）. Japanese ,Chinese Han and African-American CC genotype were related with the hypertension risk （P0.05）;but the association between Caucasian and the hypertension risk was indefinite in the subgroups analysis （P=0.85）. Conclusion：The CC genotype of BDKRβ2-58T/C polymorphism might increase the hypertension risk,but this conclusion is notably affected by ethnic differences.
出处
《重庆医科大学学报》
CAS
CSCD
北大核心
2010年第10期1555-1559,共5页
Journal of Chongqing Medical University
