摘要
改进了邻溴苯基－２－唑啉的合成方法，使得Ｎ－（β－羟乙基）－２－溴苯甲酰胺在氯化亚砜作用下缩合成唑啉的收率从４０％左右提高到８４％，并避免了使用ＮａＨ试剂，为芳基－２－唑啉的合成提供一条方便、经济的路线．实验结果表明，反应温度对唑啉的收率的影响显著，随着反应温度的升高收率明显降低，室温下几乎得不到目标产物．
The synthetic method for 2(2bromophenyl)oxazoline was modified. The condensation reaction of N(hydroxyethyl)obromobenzamide to corresponding oxaozoline is performed by using SOCl2\}, not NaH reagent, with a elevated yield of up to 84%. The experimental results show that the reaction temperature has a great influence on the oxazoline yield. The oxazoline yield drop obviously with the rising of the reaction temperature and at room temperature hardly any oxazoline product formed. Based on the results obtained, it is presumed that ehe oxazoline ring was formed via an imide tautermer intermediate.
出处
《高等学校化学学报》
SCIE
EI
CAS
CSCD
北大核心
1999年第4期569-572,共4页
Chemical Journal of Chinese Universities
基金
国家自然科学基金
关键词
恶唑啉
缩合
合成
邻溴苯基恶唑啉
Bromophenyl)oxazoline, Condensation, Heterocyclic compound
