摘要
嗜酸性粒细胞在呼吸道、肺组织局部浸润募集是支气管哮喘的特征性改变。嗜酸性粒细胞抗凋亡与促凋亡机制的失衡是导致这一改变的根本原因。其中抗凋亡因素包括白细胞介素类、TNF-α家族、CC趋化细胞因子、类脂质介质等,促凋亡因素包括生长因子类、细胞表面分子及其配体等。各种因素以不同的机制达到抗凋亡和促凋亡的作用,从而组成了复杂的调控网络,进一步影响支气管哮喘的发病。
Increasing invasive of eosinophil in bronchus and lung tissue is one of the markable changes in pathogenesis of asthma.The imbalance between proapoptosis and antiapoptosis of eosinophil is a cardinal reason contributing to the pathological change.The antiapoptosis consists of interleukins,tumor necrosis fator-α family,CC chemokines,lipid madiators,etc,the proapoptosis includes growth fators,cell surface molecule ligations,etc.Detailed mechanisms that regulate this process developing to the antiapoptotic or proapoptotic effect,compose a complicated regulatory system,sequentially contribute to the pathogenesis of the asthma.
出处
《实用儿科临床杂志》
CAS
CSCD
北大核心
2010年第22期1753-1755,共3页
Journal of Applied Clinical Pediatrics
基金
广西壮族自治区卫生厅青年基金(Z2030312)
