摘要
Ⅰ型糖尿病是胰岛β细胞破环的自身免疫性疾病。Ⅰ型糖尿病胰岛移植是治疗Ⅰ型糖尿病的有效方法。胚胎干细胞能够分化为包括胰岛素分泌细胞在内的多种细胞类型。胚胎干细胞是治疗Ⅰ型糖尿病的潜在来源。综述了近年来胚胎干细胞分化为胰岛素分泌细胞的研究进展,主要阐述了胰腺发育的转录因子和不同的分化方法。
Type 1 diabetes mellitus results from the autoimmune destruction of the insulin-secreting pancreatic beta-cells.Pancreatic islet transplantation provides curative effects on typeⅠdiabetes.Embryonic stem cells（ESCs） are pluripotent cells capable of generating many cell types.Many studies have reported that ESCs can differentiate into insulin-producing cells（IPCs）.ESCs provide an alternative source of tissue in regenerative medicine to treat Type 1 diabetes mellitus.The purpose of this review is to summarize recent progress in this area,emphasizing the transcription factors for pancreas development and the different protocols of differentiation of ESCs into IPCs.
出处
《现代生物医学进展》
CAS
2010年第21期4169-4172,共4页
Progress in Modern Biomedicine
关键词
胚胎干细胞
胰岛素分泌细胞
定向分化
embryonic stem cell
insulin-producing cells
oriented differentiation
