摘要
胰岛素(Insulin,INS)通过胰岛素信号转导途径发挥其促进合成代谢、稳定血糖的生理作用,磷脂酰肌醇-3激酶(phos-phatidylinositol-3-kinase,PI-3K)是胰岛素信号转导中的关键分子。PI-3K是由催化和调节亚基构成的异源二聚体。催化和调节亚基在数量上保持平衡,此平衡的紊乱可以改变PI-3K的活性。研究表明调节亚基p85α与胰岛素的敏感性成负相关,动物和人胰岛素抵抗(Insulin resistance,IR)发生调节亚基p85α的过度表达。
Insulin is an essential hormone for anabolic metabolism and glucose homeostasis through insulin signal transducing.Phosphatidylinositol（PI） 3-kinase play a crucial role for insulin signal transducing.PI 3-kinases exist as heterodimers which consist of an adapter regulatory subunit tightly associated with a catalytic subunit.Optimal PI 3-kinase signaling through the PI3-kinase pathway depends on a critical molecular balance between the regulatory and catalytic subunits,a disrupted balance between the levels of the PI3-kinase subunits may alter PI3-kinase activity.Several recent studies have suggested that increased p85α is a potent negative regula-tor of insulin signaling,and increased expression of p85αwas found in animals and human beings.
出处
《现代生物医学进展》
CAS
2010年第21期4160-4162,共3页
Progress in Modern Biomedicine
关键词
磷脂酰肌醇-3激酶
胰岛素抵抗
信号转导
phosphatidylinositol- 3- kinase
Insulin resistance
signaling transmission
