摘要
目的观察阿托伐他汀对急性脑梗死（ACI）患者血清白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和肿瘤坏死因子-α（TNF-α）水平的影响。方法120例ACI患者按数字表法随机分为观察组（60例）和对照组（60例），另选同期健康查体正常人35名为健康组。对照组给予常规治疗，观察组在常规治疗基础上加用阿托伐他汀治疗，20mg／次，1次／d，连服4周，观察两组治疗前后IL-6、IL-8及TNF-α水平的变化情况，并与健康组相比较。结果观察组和对照组IL-6、IL-8及TNF一仅水平较健康组明显升高（均P〈0．05）；治疗4周后，观察组及对照组IL-6、IL-8及TNF-α水平均较治疗前明显下降（均P〈0．05），且观察组较对照组下降更明显（均P〈0．05）。结论阿托伐他汀能明显降低ACI患者血清IL-6、IL一8及TNF-α水平，具有减轻炎性反应作用。
Objective To study the effect of atorvastatin on the levels of serum IL-6,IL-8 and TNF-α in patients with acute cerebral infarction. Methods 120 patients with ACI were randomly divided into the atorvastatin therapy group（ n = 60） and the conventional therapy group（ n = 60）. At the basis of conventional therapy, the Atorvastatin therapy group was treated with Atorvastatin 20mg/d. Both groups were treated for 4 weeks. The levels of serum IL-6,IL-8 and TNF-α were measured before and after treatment. A healthy control group which approximately matched the experimental group included 35 persons. Results The levels of serum IL-6 ,IL-8 and TNF-a in ACI patients were higher than control group, （P 〈 0. 05）. No difference of IL-6,IL-8 and TNF-α were found between the atorvastatin group and the control group before treatment（ P 〉 0.05 ）. Both two groups after 4 weeks treatment were significantly lower than those before treatment（ all P 〈0. 05） ,and the level of serum IL-6,IL-8 and TNF-α in Atorvastatin therapy group were significantly lower than that in conventional therapy group （ P 〈 0. 05 ）. Conclusion The IL-6, IL-8 and TNF-α played an important role in the pathogenesis of ACI. Atorvastatin could significantly decrease the level of serum IL-6,IL-8 and TNF-α. Atorvastatin had anti-inflammatory effects and neuroprotection role.
出处
《中国基层医药》
CAS
2010年第21期2909-2910,共2页
Chinese Journal of Primary Medicine and Pharmacy
