摘要
目的研究细胞免疫致卒中后抑郁(PSD)可能的机制,探讨IL-1β、IL-6与PSD发生的相关性。方法采用酶联免疫吸附法检测经汉密尔顿评测的卒中后抑郁90例患者和对照组30例患者的IL-1β、IL-6浓度;观察血清IL-1β、IL-6浓度水平变化。结果卒中后患者血清IL-1β、IL-6浓度水平变化高于对照组,有明显差异性(P<0.01)。结论 1)IL-1β、IL-6与卒中后抑郁有显著相关性,提示细胞因子可能在器质抑郁状态的发病机理中起重要作用。2)PSD患者的血清IL-1β、IL-6升高。3)PSD患者的抑郁程度与其的血清IL-1β、IL-6浓度水平呈正相关。
Objective To study cellular immunity change of the post-stroke depression（PSD） and its possible mechanism of onset.To investigate the relationship between serum cytokines（IL-1β IL-6）and PSD.Methods By using ELISA,Plasma interleukin-1beta（IL-1β）,interleukin-6（IL6）in 90PSD patients whose clinical evaluation was performed by the Hamilton voting scale for depression（HAMD）.Plasma interleukin-1beta（IL-1β）,interleukin-6（IL-6）in 30patients who were in controls.Results Plasma intorleukin-1beta,interleukin-6in post-stroke depression were obviously higher than that in controls（P0.01）.Conclusions These findings further show that an activation of the immune-inflammatory system is involved in the pathoph-ysidogy of post-stroke depression disorders,and it determines the severity of post-stroke depression which is associated with plasma concentrations of IL-1beta,IL-6before treatment.The degree of the neurological deficits and IL-1beta,IL-6show a significant relationship with the degree of PSD.
出处
《齐齐哈尔医学院学报》
2010年第20期3210-3212,共3页
Journal of Qiqihar Medical University
关键词
白介素-1Β
白介素-6
卒中后抑郁
细胞因子
Interleukin-1beta（IL-1β） Interleukin-6（IL-6） Post-stroke depression Cytokines
