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血糖波动与氧化应激 被引量：10

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摘要 传统观点认为糖尿病并发症由晚期糖基化终产物（AGEs）、多元醇通路、蛋白激酶c（PKC）、己糖胺途径激活所致，而Brownlee证明线粒体活性氧簇（ROS）生成过多可能是糖尿病并发症发生的共同机制。良好的血糖控制是延缓或阻止糖尿病慢性并发症发生发展的重要措施，糖化血红蛋白（HbAlc）是反映长期血糖控制的金标准。然而糖尿病控制与并发症试验（DDCT）表明，即使HbAlC水平相同，并发症发生的风险也不相同。基于这一结果的推测是，
作者 李红 李霖
机构地区 浙江大学医学院附属邵逸夫医院内分泌科
出处 《中华医学杂志》 CAS CSCD 北大核心 2010年第42期2956-2958,共3页 National Medical Journal of China
关键词 氧化应激 血糖波动 糖尿病并发症 晚期糖基化终产物 糖尿病慢性并发症 线粒体活性氧簇 糖化血红蛋白 血糖控制
分类号 R686 [医药卫生—骨科学]
  • 相关文献

参考文献16

  • 1Brownlee M.Biochemistry and molecular cell biology of diabetic complications.Nature,2001,414:813-820.
  • 2Johansen JS,Harris AK,Rychly DJ,et al.Oxidative stress and the use of antioxidants in diabetes:linking basic science to clinical practice.Cardiovasc Diabetol,2005,4:5-15.
  • 3Nishikawa T,Sasahara T,Kiritoshi S,et al.Evaluation of urinary 8-hydroxydeoxy-guanosine as a novel biomarker of macrovascular complications in type 2 diabetes.Diabetes Care,2003,26:1507-1512.
  • 4Evans JL,Goldfine ID,Maddux BA,et al.Are oxidative stressactivated signaling pathways mediators of insulin resistance and beta-cell dysfunction? Diabetes,2003,52:1-8.
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二级参考文献26

  • 1贾伟平,潘洁敏,陈蕾,吴元民,陆俊茜,项坤三.空腹血糖受损切点变化与糖尿病及心脑血管事件风险的关系——上海华阳社区40岁以上人群的随访研究[J].中华内分泌代谢杂志,2004,20(5):392-395. 被引量：87
  • 2王先令,陆菊明,潘长玉.动态血糖监测系统的临床应用[J].军医进修学院学报,2005,26(1):63-65. 被引量：39
  • 3周健,贾伟平,李鸣,陆俊茜,马晓静.动态血糖监测胰岛素瘤一例并文献复习[J].上海医学,2006,29(4):211-213. 被引量：3
  • 4周健,喻明,贾伟平,李青,李鸣,马晓静,陆蔚,项坤三.应用动态血糖监测系统评估2型糖尿病患者日内及日间血糖波动幅度[J].中华内分泌代谢杂志,2006,22(3):286-288. 被引量：178
  • 5Monnier L, Mas E, Ginet C, et al. Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes. JAMA, 2006, 295:1681-1687.
  • 6Gopaul NK, Anggard EE, Mallet AI, et al. Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus. FEBS Lett, 1995, 368:225-229.
  • 7Murai Y, Hishinuma T, Suzuki N, et al. Determination of urinary 8-epi-prostaglandin F (2alpha) using liquid chromatography- tandem mass spectrometry: increased excretion in diabetics. Prostaglandins Other Lipid Media, 2000, 62 : 173-181.
  • 8McDonnell CM, Donath SM, Vidmar SI, et al. A novel approach to continuous glucose analysis utilizing glycemic variation. Diabetes Technol Ther, 2005, 7 : 253-263.
  • 9Mezzetti A, Cipollone F, Cuccurullo F, et al. Oxidative stress and cardiovascular complications in diabetes: isoprostanes as new markers on an old paradigm. Cardiovasc Res, 2000, 47:475-488.
  • 10Morrow JD. Quantification of isoprostanes as indices of oxidant stress and the risk of atherosclerosis in humans. Arterioscler Thromb Vasc Biol, 2005, 25 : 279-286.

共引文献32

同被引文献81

引证文献10

二级引证文献75

中华医学杂志
2010年 第42期

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