摘要
系统性红斑狼疮（SLE）是一种以免疫细胞活化和自身抗体产生为特征的自身免疫病。间充质干细胞（MSC）是属于中胚层的一类多能干细胞，不仅具有多向分化潜能，还有多种免疫调节作用。许多研究表明MSC对可以通过调节免疫细胞（上调Foxp3’T细胞水平、下调Th17细胞水平、抑制浆细胞的成熟等）的表达以及细胞因子（IL-10、TGF—β、TNF—α等）的分泌干预抑制SLE，并且免疫原性较低。尤其脐带MSC，因为其独特优势，目前已经成为干细胞干预治疗SLE的研究热点。
Systemic lupus erythematosus （SLE） is an autoimmune disease characterized by the activation of immune cells and production of autoantibodies by plasma cells and release of cytokines. Mesenchymal stem ceils （MSC） are widely studied as an alternative cell source for their ability to differentiate into multiple mesenchymal lineages. An important function for MSC for autoimmune diseases is their immunomodulatory effect on various activated lymphoid cells, such as T cells B cells, NK cells, and dendritic cells; and on cytokines , such as IL-10, TGF-β, TNF-α, et al. Umbilical cord MSCs （UC-MSCs） had a higher proliferation capacity and lower immunogenicity, indicating that it may be a novel alternative source of human MSC for clinical application. In this review, we introduce the immunomodulatory effect and clinical application of UC-MSC in SLE based on recent findings in human and animal models.
出处
《国际免疫学杂志》
CAS
北大核心
2010年第6期459-462,共4页
International Journal of Immunology
基金
安徽省卫生厅基金资助项目（20LOC078）
关键词
脐带
间充质干细胞
红斑狼疮
系统性
Umbilical cord
Mesenchymal stem cells
Lupus erythematosus
Systemic
