摘要
目的研究血管紧张素Ⅰ转化酶（ACE）基因多态和2型糖尿病肾病（DN）的关系。方法用PCR技术检测102例中国汉族2型糖尿病患者ACE基因1／D多态基因型。结果DN组（n＝36）和无DN组（n＝49）相比，D型等位基因和DD基因型频率升高（分别为59．7％vs38．8％，X2＝7．30；33．3％vs12．2％，X2＝5．53），有显著性差异（P＜0．05）。病程≤5年合并DN组（n＝11）与病程＞5年无DN组（n＝20）相比，DD基因型频率增高（45．5％vs20．0％，X2＝4．27，P＜0．05）。标化多元逐步回归分析发现依次进入回归方程的是年龄、果糖胺和病程，而基因型未进入方程。结论ACE基因I／D多态和DN有相关性，和某些患者早期发展为DN有关，但在DN的发生发展中是微效基因。
Objective To study the association of an insertion/deletion (I/D) polymorphism of angiotensin Iconverting enzyme (ACE) gene with diabetic nephropathy (DN). Methods PCR technique was used to determine theACE gene genotypes in 102 cases of Chinese type 2 DM patients. Results in comparison of DN group with non--DNgroup it was found that there was an association of D type allele with DN (X'~ 7' 30, P <0. 05),and DD genotype wasmore frequent in DN group(X' = 5' 53' P <0. 05). Also, DD genotype was prevalent in DN group of short duration (n= 11 ) than non--DN patients with long duration (n ~ 20) (X' ~ 4. 27, P < 0. 05). By standard multiple stepwiseregression, it was found that l/D polymorphism of ACE gene could not enter the regression equation. ConclusionPatients carrying DD genotype and D type allele are susceptible to DN. ACE gene polymorphism is associated with earlyoccurrence and development of DN in some patients, but it is a microeffective gene.
出处
《中国糖尿病杂志》
CAS
CSCD
1999年第3期138-140,共3页
Chinese Journal of Diabetes
