摘要
目的研究彩色超声多普勒（ＣＤＦＩ）及血浆ＯＸＬＤＬ水平在诊断颈动脉粥样硬化（ＣＡＳ）病变中的价值。方法应用ＣＤＦＩ检查１６８例颈动脉（ＣＡ），以ＣＡ内膜厚度、斑块情况、狭窄程度的超声分级和病理学分型作为评价ＣＡＳ硬化程度的指标。从中筛选出６６例，分为ＣＡＳ组和正常对照组，进行血脂、低密度脂蛋白（ＬＤＬ）及氧化修饰型ＬＤＬ（ＯＸＬＤＬ）水平测定。ＣＡＳ组再分为糖尿病ＤＭ（＋）和ＤＭ（－）组。将所有结果逐一对比分析。结果ＣＤＦＩ检出阳性患者１２５例。ＣＡＳ组ＯＸＬＤＬ水平明显高于对照组（Ｐ＜０００１），具有显著性差异；ＤＭ（＋）组显著高于ＤＭ（一）组（Ｐ＜００５）。分析表明血浆ＯＸＬＤＬ水平增高是致ＡＳ的危险因素之一。超声检查能发现早期临床无症状的ＣＡＳ，并能够提示ＣＡＳ斑块造成ＣＡ狭窄程度。结论ＣＤＦＩ与ＯＸＬＤＬ检查联合应用可为预防ＣＡＳ的形成，早期发现及治疗提供可靠的依据。
Purpose To study the role of
color Doppler flow imaging (CDFI) and plasma OX low-density lipoproteins (LDL) in CAS
patients.Methods To estimate CAS,the carotid (CA) ultrasound examinations were performed by
CDFI in 168 patients,classified into the various degrees according to pathology and stricture of
ultrasound IMT’s thickness,spot-types.Among them,66 patients were divided into CAS(+) and
CAS(-),and their blood was examined for cholesterol (CHO),triglyceride (TG),plasma LDL and
OXLDL.The CAS(+) group consists of Diabetes DM(+) and DM(-) patients.Results 125 cases
were diagnosed as CAS by carotid CDFI.The plasma OXLDL levels of CAS(+) patients were
significantly higher than CAS(-) ( P <0 001),DM(+) than DM(-) ( P <0 05).The analysis
indicated that OXLDL was one of the main risk factors of CAS,meanwhile,non symptom,plaque
and stricture degrees of CAS were able to be characterized early using CDFI.Conclusion The
study demonstrated that combination use of these two examination strategies might be
valuable to prevent the formation,early diagnosis and treatment of CAS. [
出处
《中国医学影像技术》
CSCD
北大核心
1999年第6期442-444,共3页
Chinese Journal of Medical Imaging Technology
