摘要
目的探索股骨头缺血坏死（ＡＶＮ）介入治疗可行性的客观依据。方法取健康成年新西兰兔２０只，随机分成三组：Ａ组（正常对照）５只；Ｂ组（模型组）５只，Ｃ组（治疗组）１０只。将溶栓药物、扩血管药物和改善微循环药物直接注入股骨头供血动脉，借助经腹主动脉灌铅、ＭＲＩ和组织学检查，对比观察了三组各项指标的变化。结果①和对照组比较，模型组股骨颈、干Ｔ２ＷＩ信号增高，尤以ＳＴＩＲ明显，治疗组股骨颈、股骨干ＭＲＩＴ２ＷＩ及ＳＴＩＲ序列高信号基本恢复；②和模型组比较，股骨头供血动脉数目有明显增加（Ｐ＜０．００１）；③股骨头空缺骨陷窝数明显减少（Ｐ＜０．００５），软骨下血管数量及血管直径明显增加（Ｐ＜０．０５）。结论介入溶通疗法可改善激素性缺血股骨头的血供，对早期股骨头缺血坏死是一种有效的治疗方法。
Objective
To find the experimental evidence for interventional therapy used in avascular necrosis of
femoral head.Methods 20 rabbits were randomly divided into 3 groups:Group A(normal control),
B(model), and Group C(treatment).On the basis of hormone induced AVN
model,Urokinase,Dextran and injectio salviae miltiorrhizae were infused into the supplying
arteries directly.MR signal,the number of supplying artery,and the histological changes were
observed and compared between each group.Results ①Compared with control group,the MRI T
2WI signal in model group became higher,especpally in STIR sequence and nearly return to
normal in group C.②The number of supplying artery in group C increased with great
significance compared with group B ( P <0.001).③The number of empty lacuna is decreased (
P <0.005),while the subchondral vascular number in group C is increased with great significant
difference ( P <0.05) compared with group B.Conclusion Interventional therapy can improve
the blood supplying of hormone induced AVN,which is an effective method in the treatment of
early AVN of the femoral head. [
出处
《中国医学影像技术》
CSCD
北大核心
1999年第6期416-416,共1页
Chinese Journal of Medical Imaging Technology
基金
安徽省高校自然科学基金
关键词
股骨头
缺血性坏死
激素性
溶通治疗
Femoral head Avascular necrosis Interventional
radiology Animal Experiment
