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PLGA及PLGA/β-TCP支架的降解对细胞生长的影响 被引量：2

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摘要 在聚(L-丙交酯-co-乙交酯)(PLGA)和PLGA/β-磷酸三钙(β-TCP)多孔支架上种植成骨细胞,考察支架对细胞活性的影响,重点研究静/动态体外降解一定时间(4,8,12周)后的PLGA和PLGA/β-TCP支架上细胞的增殖情况.结果表明,PLGA和PLGA/β-TCP两种支架均具有良好的细胞相容性,可为细胞的生长提供良好的模板,但PLGA的降解会影响细胞的活性,且细胞活性随支架降解程度的增加而降低.
作者 杨艳芳 唐功文 赵蕴慧 张杨 李秀兰 袁晓燕
机构地区 天津大学材料科学与工程学院 天津市天津医院骨科研究所
出处 《科学通报》 EI CAS CSCD 北大核心 2010年第30期2910-2914,共5页 Chinese Science Bulletin
基金 国家自然科学基金资助项目(10672015 30828008)
关键词 PLGA Β-TCP 支架 降解 成骨细胞
分类号 R318.08 [医药卫生—生物医学工程]
  • 相关文献

参考文献13

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共引文献18

同被引文献20

  • 1杨自权,卫小春,焦强,陈崇伟,郝一勇,李鹏翠,丁娟.自体骨髓间充质干细胞移植修复兔关节软骨损伤[J].中华创伤杂志,2005,21(3):183-186. 被引量：23
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科学通报
2010年 第30期

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