摘要
采用硅烷偶联剂(KH550)和L-丙交酯LLA联合接枝处理的新方法对纳米羟基磷灰石(n–HA)进行表面改性,然后将其与聚乳酸-羟基乙酸(PLGA)作不同比例复合(n-HA为3wt%、10wt%、20wt%及30wt%),得到改性n-HA/PLGA复合材料(g-n-HA/PLGA)。将其与未改性n-HA及未改性n-HA/PLGA复合材料作对比检测。结果表明,该联合处理方法是n-HA进行表面接枝改性的新型有效方法。且改性处理后的n-HA与未改性处理的n-HA相比,能更好地在PLGA基体中分散均匀,并能提高PLGA结晶能力和PLGA的力学性能。当改性处理后的n-HA添加量为10wt%时,其复合材料抗弯强度和拉伸强度分别比未改性n-HA/PLGA提高14.4%和11.3%。该新型g-n-HA/PLGA复合材料有望用作骨折固定材料。
Nano-hydroxyapatite（n-HA） was modified by a new method of combining silane coupling reagent（KH550） with surface-grafting L-lactide LLA.Then,the surface-modified n-HA（g-n-HA） was introduced into poly（lactic-co-glycolic acid）（PLGA） to prepare a series of g-n-HA/PLGA composites with the concentration of 3wt%,10wt%,20wt% and 30wt%.The properties of the g-n-HA/PLGA composites were characterized and compared with PLGA and n-HA/PLGA composites.The results show that n-HA is successfully modified by KH550 and L-LA.The g-n-HA particles could disperse more uniformly in PLGA matrix and promote PLGA to crystallize.The obtained g-n-HA/PLGA composites has better mechanical properties than those of n-HA/PLGA composites with the same amount of n-HA.Moreover,the bending and tensile strength of g-n-HA/PLGA composite containing 10wt% g-n-HA are 14.4% and 11.3% which is higher than that of pure PLGA,respectively.Therefore,the g-n-HA/PLGA composite is promising for bone fracture internal fixation material in future.
出处
《无机材料学报》
SCIE
EI
CAS
CSCD
北大核心
2013年第7期751-756,共6页
Journal of Inorganic Materials
基金
中国科学院"西部之光"人才培养计划项目
国家自然科学基金(31000440)~~
