摘要
目的探讨细胞因子在精神分裂症病理、生理机制中的作用。方法采用放射免疫法对78例首发精神分裂症患者和35名正常人的血浆白细胞介素1β(IL-1β)、白细胞介素2(IL-2)、白细胞介素6(IL-6)、白细胞介素8(IL-8)、α-肿瘤坏死因子(TNFα)进行检测,同时用阳性与阴性症状量表(PANSS)评定精神分裂症患者精神症状。结果精神分裂症患者血浆IL-1β、IL-6、IL-8、TNFα水平均显著高于正常对照组,IL-2显著低于正常对照组。结论提示精神分裂症患者的免疫功能处于亢进状态,细胞因子与精神病理之间有着一定关系。
Objective To investigate the action of cytokines in pathophysiological mechanisms of schizophrenia.Methods The method of using RIA（rich internet application）to measure plasma interleukin 1β（IL-1β）,interleukin 2（IL-2）,interleukin 6（IL-6）,interleukin 8（IL-8）,and alpha tumor necrosis factor（TNF a）from 78 cases of starting schizophrenia patients and 35 normal individuals,simultaneously using the positive and negative symptoms scale（PANSS）to evaluate the psychotic symptoms of schizophrenia patients.Results Schizophrenic patient＇s levels of plasma IL-1β,IL-6,IL-8,TNFα were significantly higher than normal control group,howerver,IL-2 is significantly lower than normal controls.Conclusion The immune function of prompting schizophrenia patients is in the condition of hyperfunction,cell factor has a definite relationship with psychopathology.
出处
《四川精神卫生》
2010年第4期209-211,共3页
Sichuan Mental Health
