摘要
目的探讨炎性因子及烟碱型乙酰胆碱受体在精神分裂症发病中的作用。方法采用酶联免疫吸附法(ELISA)分别检测64例精神分裂症患者治疗前、后的血清白细胞介素2(IL-2)、白细胞介素6(IL-6)、白细胞介素1β(IL-1β)和肿瘤坏死因子α(TNFα)水平。结果精神分裂症患者血清IL-2和IL-6水平治疗前明显高于治疗后(P<0.01);另外,精神分裂症患者IL-2和IL-6水平的高低与其性别、病程、病情的严重程度及家族史有关(P均<0.01),但患者血清IL-1β和TNFα水平与对照组差异无显著性(P均>0.05)。结论中药治疗可调节精神分裂症患者炎性因子水平。炎性因子及烟碱型乙酰胆碱受体在精神分裂症发病中的作用可能与疾病的治疗有关。
Objective To explore the effects of inflammatory factor and nicotine cholinergic receptor in the onset of the schizophrenia.Methods the serum levels of interleukin-2（IL-2）,interleukin-6（IL-6）,interleukin-1β（IL-1β）,tumor necrosis factor alpha（TNFα）were measured with enzyme-linked immunosorbent（ELISA）in 64 schizophrenic patients respectively between before and after treatment.Results The serum level of IL-2,IL-6 before treatment were significantly higher than after treatment（P0.01）.In addition,the surem levels of IL-2 and IL-6 had something to do with the sexuelity,duration of illness,grave state of an illness and family history（P0.01）,but the serum levels of IL-1β and TNFαhad no significant differences in both groups（P0.05）.Conclusion The Chinese herbs had regulated effects on the serum level in patients with schizophrenia;the action of inflammatory factor and nicotine cholinergic receptor in patients with schizophrenia may relate to treatment.
出处
《哈尔滨医药》
2010年第5期47-48,共2页
Harbin Medical Journal
关键词
精神分裂症
血清炎性因子
烟碱型乙酰胆碱受体
中药治疗
Schizophrenia
Serum inflammatory factor
Nicotine cholinergic receptor
Chinese herbs treatment
