摘要
目的：了解贵州省农村少数民族妇女宫颈高危型人乳头状瘤病毒（HR-HPV）感染率和亚型分布及与HR-HPV感染相关的危险因素。方法：于2009年1月2010年2月,采用分层整群随机抽样的方法对贵州省黔南地区农村少数民族妇女2 786例进行流行病学问卷调查和HR-HPVDNA分型检测,并对与HR-HPV感染相关的因素进行单因素及多因素分析。结果：2 786例妇女中,HR-HPV感染患者为316例,总感染率为11.34%。水族妇女HR-HPV感染率与布依族、苗族、毛南族妇女之间相互比较,差异均有统计学意义（P〈0.05）。HPV感染的亚型中,HPV16（2.010%）最常见,其次为HPV33（1.759%）、58（1.364%）、52（1.256%）和31（1.149%）。单因素分析显示,婚姻状况、初次性生活年龄和妊娠次数为HR-HPV感染的危险因素（P〈0.05）。多因素分析表明,吸烟（P=0.003）、性伴侣数（P=0.023）、初次性生活年龄（P=0.198）和民族（P=0.235）为影响HR-HPV感染的独立危险因素。结论：贵州省农村少数民族妇女宫颈HR-HPV感染率低于国内平均水平,其最常见的亚型为HPV16;影响HPV感染的独立危险因素为吸烟、性伴侣数、初次性生活年龄和民族。
Objective：To determine the prevalence of cervix uteri type-specific high risk human papillomavirus（HR-HPV） infection as well as risk factors associated in rural minority of Guizhou province.Methods：A stratified random sampling study was performed in Qiannan.An epidemiological questionnaire was applied and 2786 cervix uteri specimens were obtained for liquid-based cytology and HR-HPV DNA direction.Statistical analysis included Wald Chi-squate and stepwise logistic regression model.Results：The overall HR-HPV prevalence of 2786 women was 11.34%（316/2786）.The HR-HPV prevalence of the Shui race was significant differences with the Buyi race and the Miao race and Miaonan race,respectively.13 types of HR-HPV were detected,of which HPV16（2.01%） was the most common type,followed by HPV33（1.759%）,HPV58（1.364%）,HPV52（1.256%）,and HPV31（1.149%）.Of the 316 HR-HPV infected women,18.67%（59/316） exhibited multiple HR-HPV infections.Independent risk factors for HR-HPV infection were smoking（P=0.003）,number of sex partners（P=0.023）,early age of first intercourse（P=0.198） and race（P=0.235）.Conclusion：The overall prevalence of HR-HPV infection in rural minority of Guizhou province is lower than that in China,in which the most common genotype is HPV16 and the independent risk factors for HPV infection include early age of first intercourse,smoking,number of sex partners and race
出处
《中国妇幼保健》
CAS
北大核心
2010年第32期4727-4729,共3页
Maternal and Child Health Care of China
基金
贵州省黔南布依族苗族自治州重大疾病攻关项目〔2008-05-08〕
关键词
乳头状瘤病毒感染
子宫颈
抽样调查
危险因素
Papillomavirus infections； Cervix uteri； Sampling studies； Risk factor
