摘要
背景:镁合金在骨科已进行一些初步研究,有较好的生物相容性,目前尚未在肠道进行相关基础研究。目的:镁锌合金植入大鼠盲肠,观察其与大鼠的生物相容性。方法:取SD大鼠随机区组法分为镁合金组、纯钛组和假手术组,镁合金组在盲肠切口周围包埋长约5mm×1mm×1mm镁锌合金条,纯钛组植入相同尺寸的医用纯钛条,假手术组仅做缝合。于术前、术后第7,14,21,28天,观察血清谷草转氨酶、肌酐、镁离子浓度;植入材料区X射线片;肝、肾和材料植入区盲肠病理学变化。结果与结论:各组同一时间节点血清谷草转氨酶、肌酐、镁离子浓度的差异无显著性意义(P>0.05);镁锌合金逐步降解,28d时部分降解;肝肾盲肠病理无明显异常。结果提示,镁锌合金对肠道无明显影响,其降解时间发挥固定功能时间长于肠道愈合时间,且有较好的生物相容性,可用作胃肠吻合器所用到的吻合钉。
BACKGROUND： Magnesium alloy studies in orthopedic field have been carried out, and good biocompatibility has been reported. However magnesium alloys have not yet been researched in the intestine. OBJECTIVE： The biodegradable magnesium-zinc alloy samples are implanted around the rat cecum to investigate the biocompatibility in rat. METHODS： Sprague Dawley rats were randomly divided into magnesium alloy group, medical titanium group and the sham-operated group. Then magnesium-zinc alloy samples with the dimension of 5 mm × 1 mm × 1 mm were embedded in the cecum incision in the magnesium alloy group. The medical titanium was embedded in the medical titanium group, and just suture in the sham-operated group. Prior to surgery and at 7, 14, 21 and 28 days after operation, the serum glutamic-oxaloacetic transaminase, creatinine and magnesium ion concentration were examined in each group. X-ray film on implanted region. The pathological changes in liver, kidney and cecum were examined. RESULTS AND CONCLUSION： There were no significant differences in serum glutamic-oxaloacetic transaminase, creatinine and magnesium ion concentrations among each group （P0.05）. Magnesium-zinc alloy degraded gradually during 28 days. The pathology of liver, kidney and cecum was normal. Results suggested that magnesium-zinc alloy had no obvious effect on the cecum. The degradation time to play a fixed function of time was longer than the intestinal healing time, with good biocompatibility. Magnesium-zinc alloy can be used as anastomotic nail for stomach intestine anastomat.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第42期7966-7970,共5页
Journal of Clinical Rehabilitative Tissue Engineering Research
基金
the National Natural Science Foundation of China,No.30901422~~
