摘要
背景:引导组织再生膜是引导牙周组织再生中的关键材料,临床上用于引导牙周组织的生长,它在病损组织部位提供了一个隔离的空间,从而使生长相对缓慢的牙周膜成纤维细胞重新在牙根表面生长。目的:总结引导组织再生膜的进展,为临床引导组织再生膜的研究工作提供参考依据。方法:以"Periodontal barrier membrane,guided tissue regeneration,引导组织再生,牙周"为检索词,检索2005-01/2010-05PubMed数据库、CNKI数据库中与牙周引导再生膜材料相关的临床研究和动物实验相关的文献。计算机初检得到190篇文献,根据纳入排除标准,对其中25篇文献进行分析。结果与结论:由于用于第1代引导组织再生膜的各种不可降解材料需要二次手术取出,增加患者的创伤和痛苦,影响治疗效果。目前的引导组织再生膜材料更多的趋向于生物可降解材料的研究和使用,单纯天然高分子材料由于性能的缺陷不能满足引导组织再生膜治疗要求,而与合成高分子材料结合,可以得到综合二者优异性能的医用高分子材料,使之更适合于临床应用。生物化功能性膜虽然都处于实验研究阶段,但生长因子、抗生素、黏附因子等的载入将使牙周组织再生则具有了主动促进细胞生长及诱导细胞分化的作用,具有重要的临床意义。
BACKGROUND： Guided tissue regeneration membrane is the key material in periodontal regeneration techniques, it guides gingival tissue growth clinically, excludes the epithelium from the periodontal defect, and provides an isolated space for the selective re-population of periodontal ligament, bone and cementum from the surface of dental root. OBJECTIVE： To summarize the progress of guided tissue regeneration membrane and to provide reference evidence for carrying out guided tissue regeneration membrane clinically. METHODS： Using ＂periodontal barrier membrane, guided tissue regeneration＂ in English and ＂guided tissue regeneration, periodontal＂ in Chinese as the Key words, Pubmed database and CNKI database form January 2005 to May 2010 were searched for article related to clinical studies and animal experiments of guided tissue regeneration membranes. Totally 190 literatures were screened out by computer, according to inclusive and exclusive criteria, 25 documents were involved for analysis. RESULT AND CONCLUSION： Because of the non-degradable materials, the first generation of guided tissue regeneration membranes need a second surgery to take out, thus aggravating the pains and impacting the healing. The present guided tissue regeneration membranes tend to the biodegradable materials, the pure natural bioplymers can not meet all needs of guided tissue regeneration membranes due to the property defects, while medical polymer materials, a combination with synthetic polymers, may exhibit excellent properties of the two and satisfy the clinical application. Although biological functional membranes are now under experimental study, the addition of specific agents as antibiotics, growth factors, adhesion factors, etc, conduces the periodontal tissue regeneration to promote the cell growth and induce the cell differentiation initiatively.
出处
《中国组织工程研究与临床康复》
CAS
CSCD
北大核心
2010年第42期7895-7898,共4页
Journal of Clinical Rehabilitative Tissue Engineering Research
