摘要
目的探讨轮状病毒肠炎伴良性惊厥患儿血清及脑脊液SIL-2R、IL-6、IL-8水平的变化及临床意义。方法选取临床确诊轮状病毒性肠炎伴良性惊厥患儿25例为惊厥组,同期单纯肠炎患儿25例为单纯肠炎组,因外科疾病住院手术治疗需行硬膜外麻醉的患儿35例为对照组,抽取患儿血清及脑脊液标本,检测SIL-2R、IL-6、IL-8。结果惊厥组、单纯肠炎组及对照组患儿入院24h内血清SIL-2R、IL-6、IL-8比较,差异均有统计学意义(P<0.05)。惊厥组与对照组脑脊液SIL-2R、IL-6、IL-8比较,差异均有统计学意义(P<0.05)。惊厥组和单纯肠炎组急性期及恢复期血清SIL-2R、IL-6、IL-8比较,差异均无统计学意义(P>0.05)。轮状病毒性肠炎伴良性惊厥患儿无脱水组、轻度脱水组及中度脱水组血清SIL-2R、IL-6、IL-8比较,差异均有统计学意义(P<0.05);脑脊液SIL-2R、IL-6、IL-8比较,差异均无统计学意义(P>0.05)。结论婴幼儿轮状病毒肠炎伴良性惊厥存在免疫失衡并同时导致神经细胞的病理生理改变,动态跟踪白介素的水平变化,为判断预后及病情发展提供了有效的细胞学依据。
Objective To study the changes of SIL-2R,IL-6,IL-8 of serum and cerebrospinal fluid（CSF）in children with rotavirus enteritis combined with Benign convulsions and its significance.Methods Twenty-five clinically diagnosed children with rotavirus enteritis combined with Benign convulsions（group A）,25 with simple enteritis（group B）and 35 with surgical affections（control group）were enrolled.Serum and CSF samples were taken to detect levels of SIL-2R,IL-6,IL-8.Results There was significant difference in serum SIL-2R,IL-6,IL-8 between 3 groups within 24 h after admission（P〈0.05）;group A was different from control group（P〈0.05）,but not from group B in acute and convalescent periods（P〈0.05）;there was significant difference between subgroups non-,mild-and moderate-dehydration in group A（P〈0.05）.No significant difference was noted in CSF SIL-2R,IL-6,IL-8（P〈0.05）.Conclusion Infants with rotavirus enteritis in combination with benign convulsions have immune imbalance,which leads pathophysiologic changes of nerve cells.Dynamically Tracking the changes of cell factor levels provides effective cytological basis for judgment of prognosis and progression of diseases.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第32期3612-3614,共3页
Chinese General Practice
基金
广东省中山市科技局科研立项资助项目(20071A012)
关键词
轮状病毒感染
肠炎
白介素类
Potavirvs infections
Enteritis
Interleukins
