摘要
目的探讨马蹄香治疗婴幼儿轮状病毒肠炎的作用机制,研究其对轮状病毒肠炎患儿免疫功能的影响。方法采用ELISA法检测粪便轮状病毒特异性抗原,采用透射比浊法测定血清IgG、IgA、IgM和补体C3、C4水平,采用流式细胞术分析淋巴细胞亚群。将86例轮状病毒肠炎患儿随机分为马蹄香治疗组42例,常规治疗组44例,观察两组的临床疗效、轮状病毒的排出时间及治疗前后免疫性指标的变化。结果两组患儿治疗前血清IgG、IgA、IgM和补体C3、CD3+、CD4+、CD4+/CD8+比值水平较对照组明显降低,CD1+9、CD8+水平升高,差异有统计学意义(P<0.05)。治疗后两组免疫功能均有明显改善,马蹄香治疗组显效35例,有效5例,无效2例,总有效率95.3%;常规治疗组显效30例,有效5例,无效9例,总有效率79.5%;两组总有效率间差异有统计学意义(χ2=4.7439,P<0.05)。结论马蹄香治疗婴幼儿轮状病毒肠炎的作用机制可能与抑制轮状病毒的复制,改善机体的免疫功能有关。
Objective To explore the action mechanism of Valeriana jatamansii jones （VJJ） in treating rotavlrus enteritis in infantsMethods Totally 86 infants with rotavlrus enteritis were enrolled and randomly divided into VJJ group （n = 42） and conventional therapy group （ control group ; n = 44 ）. The clinical effectiveness, excretion of rotavirus, and changes of the immunologic indicators before and after treatment were observed and recorded. Rotavirus - specific antigen was detected using ELISA. The serum levels of immunoglobulins （ IgG, IgA, and IgM） and complements （ C3 and C4 ） were measured with trans- mission turbidimetry. Lymphocyte subsets were detected with flow cytometry. Results Before the treatment, serum IgG, IgA, lgM, C3, CD3^＋ , CD4^ ＋ , CD4^ ＋/CD8^ ＋ ratio were significantly lower and CD19^＋ , CD8 ^＋ levels were significantly higher in VJJ group than in control group （ all P 〈 0.05 ） , while level of C4 had no significant change. The immune functions were remarkably improved in both groups. The effectiveness rate was 95.3% in VJJ group （ highly effective for 35 infants, effective for 5 infants, and failed in 2 infants） and 79. 5% in control group （highly effective for 30 infants, effective for 5 infants, and failed in 9 infants） （ χ^2 = 4. 7439, P 〈 0. 05 ） . Conclusion VJJ can effectively treat rotavirus enteritis in infants by inhibiting the rotavirus replication and improve immune function.
出处
《中国全科医学》
CAS
CSCD
北大核心
2010年第6期610-612,共3页
Chinese General Practice
关键词
轮状病毒感染
肠炎
免疫球蛋白类
马蹄香
药理机制
Rotavirus infections
Enteritis
Immunoglobulins
Valeriana jatamansii jones
Pharmacologic action
