摘要
目的探讨阿立哌唑和奋乃静对首发精神分裂症患者认知功能的影响。方法 86例首发精神分裂症患者随机均分为阿立哌唑组和奋乃静组,在治疗前和治疗3月后作数字广度(顺、逆)、即刻逻辑记忆、延迟逻辑记忆、即刻视觉记忆、延迟视觉记忆、连线测验A和B、字色混淆测验(Stroop)以及威斯康星卡片分类测验(W CST)等神经心理测验。结果治疗3个月后同组间相比较:阿立哌唑组除视觉记忆外其他各项认知功能指标均有所好转(即刻视觉记忆t=0.029,延迟视觉记忆t=0.032,P均>0.05;其余项目t=2.562～4.658,P<0.05或P<0.01),而奋乃静组在13项认知功能指标中有5项恶化,主要在逻辑记忆(t=2.747和3.290,P均<0.01)和执行功能方面(S troopC-W评分t=2.819,P<0.01);两组间相比较:阿立哌唑组除视觉记忆外各项认知功能测查结果均明显好于奋乃静组(即刻视觉记忆t=0.093,延迟视觉记忆t=0.048,P均>0.05;其余项目t=2.635～5.748,P<0.05或P<0.01)。结论阿立哌唑对首发精神分裂症患者的认知功能有改善作用,而奋乃静对认知功能的某些领域有损害。
Objective To compare the effects of Aripiprazole and Perphenazine on the cognitive function in first-episode schizophrenia patients.Methods A total of 86 first-episode schizophrenia patients were randomly divided into Aripiprazole group（n=43） and Perphenazine group（n=43）.Cognitive function of all the patients was blindly evaluated with Neurop sychologiacal tests,including digit span subtest,logical memory,visual reproduction,Trail Making test A and B,Stroop test and WCST before and after 3 months treatment.Results After 3 months of treatment,most of cognitive function improved significantly in Aripiprazole group except visual reproduction（logicalmemory t=0.029 and t=0.032,P〉0.05;Remaining t=2.562～4.658,P〈0.05 or P〈0.01）.While 5 neurop sychological tests deteriorated significantly in perphenazine group,mainly in memory（t=2.747 and 3.290,P〈0.01） and executive function（StroopC-W：t=2.819,P〈0.01）.The Aripiprazole group showed significantly better cognitive function than Perphenazine group in most of cognitive tests except visual reproduction（logicalmemory t=0.093 and 0.048,P〉0.05;Remaining t=2.635～5.748,P〈0.05 or P〈0.01）.Conclusion Aripiprazole treatment in first-episode schizophrenia patients may improve significantly their cognitive function while treatment with perphenazine worsen their cognitive function.
出处
《中国健康心理学杂志》
2010年第11期1283-1285,共3页
China Journal of Health Psychology
关键词
首发精神分裂症
认知功能
阿立哌唑
奋乃静
First-episode schizophrenia patients
Cognitive function
Aripiprazole
Perphenazine
