摘要
目的观察帕罗西汀合并普萘洛尔治疗焦虑症的临床疗效和不良反应。方法把205例患者随机分为研究组(帕罗西汀合并普萘洛尔)105例,对照组(帕罗西汀)100例,治疗6周。采用汉密尔顿焦虑量表(HAMA)、临床总体评价量表(CG I)评定临床疗效,采用不良反应量表(TESS)评定安全性。结果研究组和对照组的总有效率分别为87.8%和75.5%,两组差异有显著性(χ2=5.32,P<0.05),且研究组的起效时间早于对照组。研究组2、4、6周时HAMA减分率均高于对照组,并有显著性差异(F=14.58,P<0.01)。研究组头痛、心动过速、震颤等不良反应较对照组少而轻。结论帕罗西汀合并普萘洛尔治疗广泛性焦虑症具有良好的疗效和安全性,且疗效和安全性优于单独应用帕罗西汀。
Objective To observe the clinical curative effect and adverse effect of paroxetine and propranolol used in the treatment of anxiety disorders.Methods We divided 205 patients into research group（105 cases for paroxetine incorporated with propranolol） and control group（100 cases for paroxetine） randomly.The treatment last for six weeks.We used Hamilton Anxiety Rating Scale（HAMA） and Clinical Global Impression（CGI） to evaluate clinical curative effect and the safety was assessed by Treatment Emergent Symptoms Scale（TESS）.Results The total effective rate of the research group and the control group was 87.8% and 75.5% respectively.There was a significant difference between two groups in terms of the total effective rate（P〈0.05）,and the obvious effective time in research group was earlier than that in control group.The reduce rate of HAMA and HAMD in research group was significantly higher than that in control group at 2,4,6 weeks（P〈0.05）.The adverse effects such as headache,tachycardia acathisia and so on in the research group were less and lighter than that in the control group.Conclusion Paroxetine integrated with propranolol has good efficacy and safety in treating general anxiety disease,and the safety is better than paroxetine used only.
出处
《中国健康心理学杂志》
2010年第11期1281-1283,共3页
China Journal of Health Psychology
