摘要
目的探讨系统性红斑狼疮（ＳＬＥ）患者血清泌乳素（ＰＲＬ）与性激素水平的关系。方法检测３１例ＳＬＥ患者ＰＲＬ、雌二醇（Ｅ２）及睾酮（Ｔ）水平。结果ＳＬＥ患者平均ＰＲＬ水平较对照组明显升高（Ｐ＜０．０１），以活动期患者升高更为显著（Ｐ＜０．０１），同时活动期患者Ｅ２水平较对照组升高（Ｐ＜０．０５），３１例患者Ｔ水平均明显下降，与对照组比较有非常显著性差异（Ｐ＜０．０１），Ｅ２／Ｔ显著升高，血清ＰＲＬ水平与活动期患者Ｅ２水平呈正相关。结论ＰＲＬ与ＳＬＥ的发病与病情活动密切相关，可能与雌激素分泌异常有关，而雄激素有维护免疫系统的正常功能。
Objective To explore the relationship between the levels of prolactin (PRL) andsex hormones of the patients with SLE. Methods The levels of serum PRL estratiol (E2) andtestosterone (T) were measured in 31 cases SLE. Results The average levels of PRL in patientswith SLE was significantly higher than that in the controls (P<0. 01), and the levels of estradiot(E2) in cases in active stage was higher than that in the controls (P<0. 05)' The level of testosterone (T) in 31 cases decreased and compared with the controls, E,/T increased markedly (P<0' 01). The positive correlation was found between the levels of PRL and EZ in cases of activestage. Conclusion Elevated PRL has close coordination in incidence and disease activity in patientswith SLE. It shows relation with unusual secretion of estrogen. Androgen has the function to defend immune system.
出处
《临床内科杂志》
CAS
1999年第3期142-143,共2页
Journal of Clinical Internal Medicine
关键词
系统性红斑狼疮
泌乳素
性激素
Systemic lupus erythematosus
Prolactin Sex hormone
