摘要
目的探讨慢性乙型重型肝炎免疫学指标变化的规律及其与近期疗效的关系。方法对65例慢性乙型重型肝炎和15例健康体检人群分别采用流式细胞仪、快速免疫消浊比浊法进行外周血T淋巴细胞亚群、IgG、总补体溶血活性CH50(CH50)、补体C3(C3)的检测。结果慢性乙型重型肝炎CD3+、CD4+T淋巴细胞计数均低于正常组,晚期低于早、中期(P<0.05),CD4+/CD8+比值高于正常组,晚期高于早、中期(P<0.05)。IgG明显高于正常组,且晚期较早、中期进一步升高(P<0.05),CH50、C3低于正常组,晚期低于早期(P<0.05)。结论慢性乙型重型肝炎患者存在免疫功能紊乱,可能存在细胞免疫功能低下与体液免疫功能亢进,随着疾病进展其有加重趋势。
Objective To investigate the changes in the immunological parameters in patients with chronic severe hepatitis B and the relationship with therapeutic efficacy in the near future. Methods Flow cytometry and immunoturbidimetry were used to determine T lymphocyte subsets in peripheral blood, immunoglobulin G （IgG）, 50% complement hemolytic activity （CH50） and complement 3 （C3） in 65 patients with chronic severe hepatitis B （severe hepatitis group） and 15 healthy controls （normal group）. Results CD3＋ and CD4＋ T lymphocyte counts in the severe hepatitis group were lower than those in the normal group, and those of the patients with advanced stage were lower than those of the patients with early and middle stage （P〈0.05）. CD4＋/CD8＋ ratio in the severe hepatitis group was higher than that in the normal group, and that of the patients with advanced stage was higher than that of the patients with early and middle stage （P〈0.05）. IgG in the severe hepatitis group was significantly higher than that in the normal group, and that of the patients with advanced stage was higher than that of the patients with early and middle stage （P〈0.05）. CH50 and C3 in the severe hepatitis group were lower than those in the normal group, and those of the patients with advanced stage were lower than those of the patients with early stage （P〈0.05）. Conclusion The patients with chronic severe hepatitis B have disorder of immune function, i.e. lowered cellular immune function and humoral immune hyperfunction, and may aggravate with the progres- sion of the disease.
出处
《传染病信息》
2010年第5期285-286,290,共3页
Infectious Disease Information
基金
国家"十一五"科技重大专项(2008ZX10005-007)
