摘要
目的：研究大鼠脑缺血再灌流体感诱发电位（ＳＥＰ）变化。方法：建立脑缺血再灌流动物模型，随机分成正常对照组９只，缺血和再灌流组２９只，在缺血１ｈ、２ｈ和再灌流１ｈ分别进行神经功能缺损评分，于缺血２ｈ再灌流１ｈ进行ＳＥＰ观察。结果：大鼠脑缺血时，神经功能缺损以轻、中度局灶性损害为主要表现，再灌流后变化不明显，只有１只体征加重。ＳＥＰ检测缺血、再灌流组与正常对照组比较，Ｐ１、Ｎ１峰值潜伏期延长，Ｐ１Ｎ１峰峰波幅降低（Ｐ＜００１），缺血组与再灌流组比较，Ｐ１、Ｎ１峰值潜伏期、Ｐ１Ｎ１峰峰波幅没有显著差异（Ｐ＞００５）。结论：ＳＥＰ是研究大鼠脑缺血再灌流有效可靠的手段，它能较早反映脑缺血及大脑神经功能的改变。
Objective: To study the changes of somatosensory evoked
potential(SEP)inexperimental brain ischemia-reperfusion in rats. Methods: An animal model of
brain ischemia-reperfusion was established in rats.The rats were divided randomly into normal
control group(n=9) and ischemia-reperfusion group(n=29).The neurological deficit scores were
determined one and two hours after brain ischemia and one hour after reperfusion,and SEP was
studied two hours after ischemia and one hour after reperfusion. Results: Mild and moderate
neurological deficits were main manifestation in brain ischemia rats and there were not
significant changes in neurological deficits after reperfusion.The exacerbation of neurological
deficit was noted only in one rat.The latencies of P1 and N1 wave were prolonged and the
amplitude of P1-N1 was decreased in ischemia-reperfusion group as compared with that in
normal control group.There was not significant difference in latency and amplitude of wave P1
and N2 between ischemia-reperfusion group.ZConclusions: SEP might be a reliable means of
observing the brain ischemia-reperfusion in rat.It could reflect early the changes of brain
ischemia and the brain neurological function,also the recovers of neurological deficits after
reperfusion.
