摘要
目的：探讨尼群地平联合美托洛尔治疗1-2级高血压的临床疗效。方法：将92例患者随机分为3组：A组31例,给予尼群地平片10 mg,2-3次/d;B组31例,给予美托洛尔25-50 mg,2次/d。C组30例,给予尼群地平10 mg,2-3次/d同时加服美托洛尔12.5-25 mg,2次/d。然后每周依据血压调整1次药物剂量,尽量使血压控制在140/90 mmHg以下,疗程均为6周。结果：C组的降压效果、心率减慢以及收缩压、舒张压平均下降幅度均显著大于A,B组（P〈0.05）,不良反应的发生率较A,B组低（P〈0.05）。结论：尼群地平联合美托洛尔降压作用肯定;两药联合使用安全且价格低廉。
Objective： To evaluate of clinical effect of the combined use of Nitrendipine with Metoprolol in treating patients with level I and II hypertension.Methods： 92 patients with level I and II hypertension were randomly divided into 3 groups： group A（31 patients） took 10mg of Nitrendipine,2～3 times a day;group B（31 patients） received the treatment of 25 mg-50 mg of Metoprolol,2 times a day;while group C（30 patients） received the treatment of taking 10 mg of Nitrendipine and 12.5 mg - 25 mg of Metoprolol 2 times a day.Then,the dose of drug was adjusted based on the level of the blood pressure,which was controled under the level of 140/90 mmHg（1 mmHg = 0.133 ksPa） to the greatest extent.The course of treatment is 6 weeks without exception.Results： The effect of lowering blood pressure,the slow down of the heart rate and the decreased systolic pressure and diastolic pressure in Group C were greater than those in Group A and Group B（P〈0.05）;the incidence of drug adverse reactions was lower than that of Group A and Group B（P〈0.05）.Conclusion： The Decompression effect of Nitrendipine and Metoprolol has been confirmed.Besides,they are safe in use and economical.
出处
《华夏医学》
CAS
2010年第5期491-493,共3页
Acta Medicinae Sinica
关键词
高血压
尼群地平
美托洛尔
联合应用
hypertension
nitrendipine
metoprolol
combined application
