摘要
目的了解重庆市医疗机构就诊病例及健康人群甲型H1N1流感抗体水平,分析和预测流感的流行趋势,为制定针对性的防治措施提供依据。方法对238名门诊病例和171名健康人群进行流行病学调查并采集不同年龄组血清进行甲型H1N1流感血凝抑制试验。结果 HI总体阳性率为15.4%(95%CI:12.1%～9.4%),抗体几何平均滴度(GMT)高滴度者(≥1∶160)占阳性数的6.4%(95%CI:0.4%～19.5%);性别之间、2周前是否出现过流感样症状之间、5～岁年龄组与其余3个年龄组间和是否接种甲型H1N1流感疫苗之间阳性几何平均倒数滴度(GMRT)的差异有统计学意义(P<0.05);抗体阳性率、滴度分布和logistic回归分析结果均显示2周前出现过流感样症状者为主要影响因素,但性别、年龄间差异无统计学意义。结论重庆市甲型H1N1流感免疫水平较低,易发生流行。
Objective To investigate the antibody level to 2009 pandemic influenza A （ H1 N1 ） virus in out-patients and healthy people in Chongqing, analyze/predict the epidemic trend and provide evidence for the prevention and control of the disease. Methods Seroepidemiological survey was conducted among 238 out-patients and 171 healthy people by taken blood samples from them to detect 2009 pandemic influenza A （ H1N1 ） virus with hemagglutination inhibition （HI） test. Results The total positive rate of HI test was 15.4% （95% CI： 12.1% -9.4%）, and the people with GMT ≥ 1：160 accounted for 6.4% of the total （95% CI： 0. 4% - 19.5% ）. The differences on GMRT between males and females, the people with or without influenza like symptom 2 weeks ago, age group of 〉 5 years and the other 3 age groups as well as the people receiving the vaccination or not had statistical significance （ P 〈 0. 05 ）. The HI positivity rate, titer distribution and logistic regression indicated that the influenza like symptom 2 weeks ago was the related factors, but the differences between males and females, and among age groups had no statistical significance. Conclusion The antibody level to 2009 pandemic influenza A （H1N1） virus was low in Chongqing, and the epidemic of 2009 pandemic influenza A（ H1N1 ） might occur.
出处
《疾病监测》
CAS
2010年第10期777-780,共4页
Disease Surveillance
基金
重庆市科技攻关计划项目(No.CSTC
2009AB5176)~~
关键词
甲型H1N1流感
血凝抑制试验
抗体
LOGISTIC回归
2009 pandemic influenza A （H1N1） ： hemagglutination inhibition test： antibody- logistic regression
