摘要
目的:确定莪术残油软膏基质的最佳配比。方法:以软膏剂的外观性状,离心分层时间,耐低温,耐热恒温实验结果为考察指标,以油相、水相、乳化剂为可变因素,选用U8(86)表进行均匀设计实验,并依据其结果运用L9(34)表进行正交实验优化基质处方。结果:基质的最佳配比为:单硬脂酸甘油酯4.5g,硬脂酸10g,白凡士林5g,液体石蜡15mL,甘油10g,十二烷基硫酸钠0.22g,三乙醇胺0.22mL,尼泊金乙酯0.5g,蒸馏水50mL。结论:按此法制备的软膏符合药典规定。
Objective：To find out the best ointment of matrix composition for residual zedoary oil.Methods：Ointment in the appearance of characters,centrifugation time,cold,heat,irritation target for study.Oil phase,water phase,emulsi-fier for the variables selected U8（86） of uniform design table experiment and the results based on the use of L9（34） or-thogonal experimental table Optimize matrix prescription.Results：The best ratio of matrix：Monostearin 4.5g,Stearic acid 10g,white Vaseline 5g,liquid paraffin 15mL,glycerol 10g,sodium dodecyl sulfate 0.22g,Triethanolamine 0.22 mL,ethyl Nipagin 0.5g,distilled water 50mL.Conclusion：Click the ointment prepared in line with the Pharmacopoeia.
出处
《中华中医药学刊》
CAS
2010年第11期2447-2448,共2页
Chinese Archives of Traditional Chinese Medicine
关键词
莪术残油软膏基质
均匀设计
正交实验
Sointment of matrix
uniform design method
orthogonal design method
