摘要
对１２例肾综合征出血热（ＨＦＲＳ）患者血小板的平均截面积（Ａ）、α颗粒的面数密度（ＮＡ）、体密度（ＶＶ）及开放小管（ＯＣＳ）和丝足的均数（Ｍ）进行计量学分析。结果显示：ＨＦＲＳ患者血小板的Ａ与对照组比较差异无显著性；其血小板的丝足Ｍ显著大于对照组（Ｐ＜０．０５），ＯＣＳＭ明显小于对照组（Ｐ＜０．０５），血小板内α颗粒的面数密度显著小于对照组（Ｐ＜０．０５），体密度却显著大于对照组（Ｐ＜０．０１）。提示临床出血的主要原因除ＨＦＲＳ血小板总数减少外，因血小板的质量低下而被异常激活，导致正常的凝血、止血功能障碍也是不可忽视的因素。
To investigate the effects of stereological alteration of platelets on hemorrhage in hemorrhagic fever with renal syndrome(HFRS), platelet mean cross area(), area density of α granules(Na), volume density(V V),the mean open tubule(OCS) and pseudopodia mean() were performed stereometric analysis in 12 patients with HFRS. The platelet was observed, and no significant difference was found compared with the control( P >0.05), while the number of pseudopodia was higher, and the open tubule number was lower than those of the control( p <0.01). The results suggest that in addition to the total platelet count decrement, the quality deterioration and functional activity abnormalities of platelets play an important role on the disordered hemostasis and coagulation in HFRS.
出处
《湖南医科大学学报》
CSCD
1999年第2期123-124,149,共3页
Bulletin of Hunan Medical University
