摘要
目的观察多西紫杉醇联合氟脲嘧啶及亚叶酸钙治疗晚期胃癌的疗效和毒副反应。方法 49例晚期胃癌采用多西紫杉醇联合氟脲嘧啶及亚叶酸钙方案治疗,治疗后评价疗效和毒副反应。结果 49例均可评价疗效,其中CR3例,PR22例,SD11例,PD13例,总有效率为51.0%,中位疾病进展时间为5.5个月,中位生存期为9.3个月。毒副反应主要是骨髓抑制,其次为脱发、胃肠道反应、口腔黏膜炎、周围神经毒性。结论多西紫杉醇联合氟脲嘧啶及亚叶酸钙方案治疗晚期胃癌的疗效较好,毒副反应相对较低。
Objective To evaluate the efficacy and toxicities of the regimen of docetaxel combined with fluorouracil and calcium folinate in the treatment of patients with advanced gastric cancer.Methods Forty nine patients with advanced gastric cancer had been treated with the regimen of docetaxel combined with fluorouracil and calcium folinate.The efficacy and toxicities were evaluated.Results All the 49 cases were evaluable.Among them,3 cases achieved CR,22 cases PR,11 cases SD,13 cases PD.The overall response rate was 51.0%.Median time to progression was 5.5 months and median survival time was 9.3 months.The major toxicities were myelosuppression and alopecia,followed by gastrointestinal reaction,dental ulcer and perineural toxicity.Conclusion The regimen of docetaxel combined with fluorouracil and calcium folinate is effective for advanced gastric cancer and its toxicities are tolerable.
出处
《肿瘤基础与临床》
2010年第4期301-302,共2页
journal of basic and clinical oncology
关键词
晚期胃癌
多西紫杉醇
氟脲嘧啶
亚叶酸钙
化疗
advanced gastric cancer
docetaxel
fluorouracil
calcium folinate
chemotherapy
