摘要
目的 分析高嗜酸粒细胞综合征（HFS）心血管损害的临床特点.方法 收集北京协和医院149例HES患者的临床资料,分析心血管损害的发生率及类型.结果 149例HES患者中,心血管受累患者共49例（32.9%）,其中女性15例,男性34例,年龄1.5～78.0（41.3±16.9）岁,病程14 d～164个月（26.4±72.3）个月.其心血管受累分别表现为心电图ST-T异常或心律失常、心肌或心内膜损害、心内血栓形成、心包积液、肺动脉高压、瓣膜病变、动脉或静脉血栓形成和其他心血管损害.49例患者中11例（22.4%）经对症治疗后症状有改善但仍反复发作,3例（6.1%）患者治疗无效死亡.与单纯非特异性心电图异常患者（21例）相比,存在超声心动图异常的HES者（28例）中有更多患者需要接受激素和免疫抑制剂的联合治疗（前者使用单一激素与联合治疗分别为15例、6例,后者分别为16例、12例,P=0.044）且预后更差（两组死亡例数分别为0例与3例,P=0.029）.结论 心血管损害是HES的常见并发症,表现复杂多样,超声心动图评估心血管受累简单有效,心血管受累是提示预后的危险因素.
Objective To evaluate the cardiovascular involvements in Chinese patients with hypereosinophilic syndrome. Method We respectively reviewed 149 inpatients with hypereosinophilic syndrome admitted to Peking Union Medical College Hospital and analyzed the cardiovascular involvements in these patients. Results Cardiac abnormalities was evidenced in 32.9% patients （49/149） . The ratio of was （ 26.4 ± 72.3 ） months. Cardiovascular involvements included ST segment and/ or T wave （ST-T）ischemic changes, arrhythmia, myocardial injury, cardiac thrombosis, pericardial effusion, pulmonary hypertension, valve disorder, vein or artery thrombosis. After glucocorticoid and/or chemotherapeutic agents and treatment for symptoms, 11 （ 22.4% ） patients achieved remission but have recurrent attacks and 3 （6.1%） patients died from failure in treatment. The prognosis in patients with echocardiogram abnormalities were poorer than those only with electrocardiogram abnormalities （ P 〈 0.05 ） . Conclusions Cardiovascular involvements are common in patients with hypereosinophilic syndrome and the manifestation of these involvement is various. Cardiovascular complications of HES are a major source of morbidity and mortality in these disorders.
出处
《中华心血管病杂志》
CAS
CSCD
北大核心
2010年第10期905-908,共4页
Chinese Journal of Cardiology
