摘要
嗜酸性粒细胞增多综合征是一种涉及多学科的临床少见病,多因早期嗜酸性粒细胞未得到有效控制最终死于嗜酸性粒细胞增多性心肌病和心脏扩大引起的心力衰竭。本例患者为老年男性,以支气管哮喘、肺炎为首发症状,迁延不愈3年,嗜酸性粒细胞持续升高至72%(嗜酸性粒细胞百分比正常值为0.4%~8%),期间常年口服复方甲氧那明胶囊(商品名:阿斯美)、孟鲁司特钠片(商品名:顺尔宁)等仍控制不佳,几乎每天咳嗽,多次因支气管扩张合并感染入院治疗,3年后呼吸系统症状突然消失,转而出现以下肢足部红斑性水肿、紫癜为表现的皮肤症状及以四肢麻木、瘫痪为表现的神经源性损害症状。本研究报告了该病例发病、实验室检查、治疗、转归等完整的诊疗过程,并通过文献复习,以期对嗜酸性粒细胞增多综合征及相关疾病加深认识,做到早期诊断,正确治疗。
Hypereosinophilic syndrome is a rare clinical disease involving many disciplines.Most of them died of heart failure caused by hypereosinophilic cardiomyopathy and cardiac enlargement.This patient is an elderly man,with bronchial asthma and pneumonia as the first symptoms,which had been prolonged for 3 years,eosinophils continued to rise to 72%(eosinophil percentage normal value of 0.4%-8%).He took compound methoxypheniramine capsules(trade name:Asmeton),montelukast sodium tablets(trade name:Singulair),etc.orally during this period,but still had poor control,coughing almost every day,and was hospitalized several times for bronchodilatation.3 years later,his respiratory symptoms suddenly disappeared,and developed skin symptoms manifested by erythematous edema and purpura of the lower limbs and neurogenic damage manifested by numbness and paralysis of the limbs.This study reported the complete diagnosis and treatment process,such as the onset,laboratory examination,treatment and outcome,and through the literature review,in order to deepen the understanding of hypereosinophilic syndrome and related diseases,and achieve early diagnosis and correct treatment.
作者
陈天丽
李鹏涛
CHEN Tian-li;LI Peng-tao(Department of Dermatology,Huangdao District Central Hospital,Qingdao 266555,China)
出处
《中国实用医药》
2025年第10期161-164,共4页
China Practical Medicine
