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MTHFR基因C677T多态性与内蒙古汉族人群中冠心病的关系 被引量：2

Polymorphisms of methylenetetrahydrofolate reductase gene and coronary heart disease in Han population in Inner Mongolia
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摘要 目的:检测中国内蒙古汉族人群中MTHFR基因多态性与冠心病的关系。方法:研究组包括62例冠心病(coronaryheartdisease,CHD)患者和120例正常对照人群,用聚合酶链反应-限制性片段长度多态性技术(PCR-RFLP)分析C677T型突变。结果:677T/T基因型在冠心病人群中更普遍,是正常人群的3.4倍。结论:在内蒙古汉族人群中,677T/T基因型增加了个体患冠心病的风险性。 Objective： The objective of this study was to identify the association of MTHFR gene polymorphisms with coronary heart disease （CHD） in the Inner Mongolia Han population. Methods： The study group included 62 patients with CHD and 120 controls. Polymerase chain reaction-restriction fragmentlength polymorphism（PCR-RFLP）method was used to analyze the C677T mutations. Results： 677T/T polymorphisms was 3.4 times more common in patients with CHD than in the healthy controls. Conclusion： 677T/T genetype enhance the individual susceptibility to CHD in the inner Mongolia Han population.
作者 金慧 贺小兵 童哥
机构地区 包头市中心医院心内科
出处 《现代生物医学进展》 CAS 2010年第20期3845-3847,共3页 Progress in Modern Biomedicine
关键词 冠心病 MTHFR多态性 Congenital heart disease； MTHFR polymorphisms；
分类号 R541.4 [医药卫生—心血管疾病] Q75 [生物学—分子生物学]
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同被引文献27

  • 1肖雁,单可人,李毅,赵艳,齐晓岚,谢渊,吴昌学,马骄,刘烜,徐鹰,官志忠,任锡麟.贵州三个民族亚甲基四氢叶酸还原酶基因的遗传多态性[J].中华医学遗传学杂志,2005,22(2):219-221. 被引量：24
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现代生物医学进展
2010年 第20期

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